10.57647/j.jtap.2025.1901.14

Synergistic Cr:Au core shell Nanoparticles combination with Paclitaxel (Taxans)chemo drug on MDA breast cancer cells

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  • Ola F. Al-Salmani1,
  • Ban H. Adil*2,
  • Estabraq A. R. Al-Wasiti3,
  1. Ministry of Health, Baghdad Health Department - Al-Karkh, Technical Affairs Department, Laboratory Division, Baghdad, Iraq.
  2. Department of Physics, College of Science for Women, University of Baghdad, Baghdad, Iraq.
  3. Department of Chemistry and Biochemistry, College of Medicine, Al-Nahrain University, Baghdad, Iraq.

Received: 2024-10-02

Revised: 2024-12-10

Accepted: 2025-02-10

Published 2025-02-10

Copyright (c) 2025 Ola F. Al-Salmani, Ban H. Adil, Estabraq A. R. Al-Wasiti (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

1.
F. Al-Salmani O, H. Adil B, A. R. Al-Wasiti E. Synergistic Cr:Au core shell Nanoparticles combination with Paclitaxel (Taxans)chemo drug on MDA breast cancer cells. J Theor Appl phys. 2025 Feb. 10;19(01):1-11. Available from: https://oiccpress.com/jtap/article/view/8613
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Abstract

Dilute wild thyme extraction was synthesized onto Chrome as a core and the core-shell formed  when coated with gold by using the green-plasma jet technique. Nanoparticles created in various ratios (1:9, 2:8, 3:7). Consistent results were obtained during the examination of nanoparticles by UV examination, XRD , SEM and TEM, In addition to measuring the rate of cytotoxicity for Chrome@gold core-shell Nps and Chrme@gold core-shell Nps combined with 25 µg, 50 µg, 100µg of taxans chemo therapy  on breast cancer cell line (MDA) and in the normal cells line (REF)  and The best results was after 72 hours, Where is the

maximum rate of toxicity was in 100% concentration of NPs and the least toxicity was in 25% of NPs.

Keywords

  • Cr:Au core shell Nps,
  • Plasma jet,
  • MDA,
  • REF,
  • In vitro research,
  • Taxanes chemo drug,
  • Synergism
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