Inhibition breast cancer by (Cu-Se) nanoparticles generated by plasma jet

Abstract

This work discusses the synthesis of (Cu-Se) core-shell nanoparticles using a plasma jet, using aqueous solutions of copper and selenium salts as a precursor. The structural properties of the resultant (Cu-Se) core-shell nanostructures were examined using UV, XRD, and SEM. The diameter of the granules with a concentration of 3:7 is 17 nm. Thus, utilising the designated diameter. Next, a comparison was made between the MDA cell lineâwhich had been treated to Cu-Se NPs as an anti-cancer (breast cancer) agentâand the normal cell line REF. For every set, the following parameter was evaluated: (i) the proportion of breast cancer cells whose proliferation was inhibited after exposure for (24, 48) hours; (ii) the cytotoxicity of normal cells after (24, 48) hours. We diluted the nanomaterial five times and found that the cytotoxicity in normal cells does not exceed 22%, indicating that its effect is not detrimental to normal cells. Meanwhile, the nanomaterial's effects were observed on cancer cells after 24 hours, at roughly 63%, and after 48 hours, at roughly 93%, and the census was carried out with these cells.