Chemical composition of Leplaea mayombensis (Pellegrin) Staner

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  • Djeukeu Charlie1,
  • Hermine Laure Djomkam Maza1,
  • Kenmogne Ariane2,
  • Sewald Norbert2,
  • Wansi Duplex1,
  • Vardamides Catherine*1,
  1. Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon
  2. Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany

Revised: 2021-02-04

Accepted: 2021-05-29

Published in Issue 2021-06-01

How to Cite

Charlie, D., Djomkam Maza, H. L., Ariane, K., Norbert, S., Duplex, W., & Catherine, V. (2021). Chemical composition of Leplaea mayombensis (Pellegrin) Staner. Trends in Phytochemical Research, 5(2), 105-109. https://oiccpress.com/tpr/article/view/11800

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Abstract

One new coumarinolignan, cleomiscosin F (1) along with ten known compounds namely 3,4-secotirucalla-4(28),7,24-trien-21-hydroxy-21,23-epoxy-3-oic acid (2), 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3),ceramid A (4),ceramid B (5), mayombensin (6),aridanin (7), stigmasterol and β-sitosterol and their glucosides were isolated from the seeds and roots of Leplaea mayombensis (Meliaceae).Thestructures of the compounds were elucidated based on the interpretation of their spectroscopic data. Some of the isolated compounds (3, 4 and 5) were tested in vitro against bacteria strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, and Micrococcus luteus. Compound 3 displayed good activity against Bacillus subtilis, Micrococcus luteus, and Pseudomonas agarici with MIC values of 1.7, 2.3 and 9.8µM, respectively; while compound 4 showed significant activity against Micrococcus luteus with MIC value of 11.9µM.

Keywords

  • Minimum inhibitory concentration,
  • Antibacterial activity,
  • <i>Leplaea mayombensis</i>,
  • coumarinolignan
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