OICC Press Trends in Phytochemical Research 2588-3631 5 2 2021 06 01 Chemical composition of Leplaea mayombensis (Pellegrin) Staner 105 109 EN Djeukeu Charlie Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon Hermine Laure Djomkam Maza Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon Kenmogne Ariane Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany Sewald Norbert Organic and Bioorganic Chemistry, Department of Chemistry, Bielefeld University, 33501 Bielefeld, Germany Wansi Duplex Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon Vardamides Catherine Department of Chemistry, Faculty of Science, University of Douala, P.O. Box 24157, Douala, Cameroon Journal Article 2021 06 01 One new coumarinolignan, cleomiscosin F (1) along with ten known compounds namely 3,4-secotirucalla-4(28),7,24-trien-21-hydroxy-21,23-epoxy-3-oic acid (2), 3,4-secotirucalla-4(28),7,24-trien-3,21-dioic acid (3),ceramid A (4),ceramid B (5), mayombensin (6),aridanin (7), stigmasterol and β-sitosterol and their glucosides were isolated from the seeds and roots of Leplaea mayombensis (Meliaceae).Thestructures of the compounds were elucidated based on the interpretation of their spectroscopic data. Some of the isolated compounds (3, 4 and 5) were tested in vitro against bacteria strains Escherichia coli, Bacillus subtilis, Pseudomonas agarici, and Micrococcus luteus. Compound 3 displayed good activity against Bacillus subtilis, Micrococcus luteus, and Pseudomonas agarici with MIC values of 1.7, 2.3 and 9.8µM, respectively; while compound 4 showed significant activity against Micrococcus luteus with MIC value of 11.9µM.