Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions

Authors

• Farzaneh Mohamad Pour ¹
• Malek Taher Maghsoodlou ²
• Reza Heydari ³
• Mojtaba Lashkari ⁴

1. Department of Chemistry, Faculty of Science, University of Sistan and Baluchestan, P. O. Box 98135-674 Zahedan, Iran.
2. Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran
3. Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
4. Faculty of Science, Velayat University, Iranshahr, Iran.

Abstract

Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of
3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy.

Keywords

• Oxalic acid.2H2O
• Green methodology
• 4-Dihydropyrimidinone.
• Biginelli reaction