TY - EJOUR
AU - Pour, Farzaneh Mohamad
AU - Maghsoodlou, Malek Taher
AU - Heydari, Reza
AU - Lashkari, Mojtaba
PY - 2024
DA - February
TI - Oxalic acid dihydrate catalyzed synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives under thermal and solvent-free conditions
T2 - Iranian Journal of Catalysis
VL - 6
L1 - https://oiccpress.com/iranian-journal-of-catalysis/article/oxalic-acid-dihydrate-catalyzed-synthesis-of-34-dihydropyrimidin-2-1h-one-derivatives-under-thermal-and-solvent-free-conditions/
N2 - Oxalic acid dihydrate as a green, mild and efficient catalyst for the one-pot three-component Biginelli synthesis of 3,4-dihydropyrimidin-2-(1H)-one derivatives from the reaction between β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehye derivatives) and urea or thiourea under thermal and solvent-free conditions with excellent yields and short reaction time is studied. The most remarkable benefits of this synthetic method include the green methodology, an eco-friendly, inexpensive and non-toxic catalyst, solvent-free conditions, the availability of materials, and a simple operational procedure with no column chromatographic separation. The products were characterized by melting points, IR and 1H NMR spectroscopy.
IS - 2
PB - OICC Press
KW - Biginelli reaction, Oxalic acid.2H2O, Green methodology, 4-Dihydropyrimidinone. 
EN -