Study of the antileukemic activity of Mimosa caesalpiniifolia Benth. ethanolic extract and fractions

PDF
  • Gabriele Taumaturgo Mororó1,
  • José Roberto de Oliveira Ferreira2,
  • Michel Mualén de Morais Alves1,
  • Nayana Bruna Nery Monção3,
  • Laís Campos Teixeira de Carvalho-Gonçalves4,
  • Antônia Maria das Graças Lopes Citó3,
  • Paulo Michel Pinheiro Ferreira5,
  • Fernando Aécio de Amorim Carvalho1,
  • Juan Carlos Ramos Gonçalves1,
  1. Núcleo de Pesquisas em Plantas Medicinais, Universidade Federal do Piauí, Teresina-PI, Brasil
  2. Programa de Pós-Graduação em Ciências Farmacêuticas, Universidade Federal do Piauí, Teresina-PI, Brasil
  3. Departamento de Química, Universidade Federal do Piauí, Teresina-PI, Brasil
  4. Centro de Biotecnologia, Universidade Federal da Paraíba, João Pessoa-PB, Brasil
  5. Departamento de Biofísica e Fisiologia, Laboratório de Cancerologia Experimental, Universidade Federal do Piauí, Teresina-PI, Brasil

Revised: 2018-02-24

Accepted: 2018-09-20

Published in Issue 2018-09-01

How to Cite

Mororó, G. T., de Oliveira Ferreira, J. R., de Morais Alves, M. M., Nery Monção, N. B., de Carvalho-Gonçalves, L. C. T., Graças Lopes Citó, A. M. das, Pinheiro Ferreira, P. M., de Amorim Carvalho, F. A., & Ramos Gonçalves, J. C. (2018). Study of the antileukemic activity of Mimosa caesalpiniifolia Benth. ethanolic extract and fractions. Trends in Phytochemical Research, 2(3), 127-134. https://oiccpress.com/tpr/article/view/11725

PDF views: 204

Abstract

Mimosa caesalpiniifolia Benth. is a native plant to northeastern Brazil, traditionally used in folk medicine, with several pharmacological activities reported including antibacterial, anti-inflammatory, and antitumor. The present study evaluated the antileukemic potential of M. caesalpiniifolia Benth. ethanolic extract (EtOH) and its n-hexanic (HexF) and dichloromethane (DCMF) fractions. Previous analysis by our team revealed the constituents of high relative abundance in EtOH, HexF, and DCMF, like phytol (11.7%), lupeol (14.7%), and betulinic acid (70.3%), respectively. In the MTT cell viability test, EtOH, HexF, and DCMF induced dose-dependent cytotoxicity in human chronic myeloid cells (K562), with IC50 of 153.6 ± 0.1, 118.40 ± 0.2, and 40.0 ± 0.1 μg/mL, respectively (p <0.05). Additionally, DCMF (6-800 μg/mL) presented minor toxicity against normal human erythrocytes and murine macrophage cells. DCMF induced similar antileukemic effects (IC50=64.2 ± 5.0 μg/mL) against human acute myeloid cells (HL-60). However, it did not exert antitumor activity on murine sarcoma (S180) cells (p >0.05).
PDF