A new lupane triterpene glycoside from Euphorbia boissierana Prokh.

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  • Lili Gvazava1,
  • Nana Gorgaslidze1,
  • Markus Ganzera2,
  • Alexander Skhirtladze*1,
  1. TSMU Iovel Kutateladze Institute of Pharmacochemistry, 36 P. Sarajishvili st., 0159 Tbilisi, Georgia
  2. Pharmacognosy, Institute of Pharmacy, University of Innsbruck, Innsbruck, Austria

Revised: 2017-06-14

Accepted: 2017-08-12

Published in Issue 2017-09-01

How to Cite

Gvazava, L., Gorgaslidze, N., Ganzera, M., & Skhirtladze, A. (2017). A new lupane triterpene glycoside from Euphorbia boissierana Prokh. Trends in Phytochemical Research, 1(3), 149-152. https://oiccpress.com/tpr/article/view/11697

PDF views: 156

Abstract

Euphorbia plants displayed a wide range of biological activities including anticancer, antitumor, anti-diabetic, anticoagulant, antiproliferative, antioxidant, cytotoxic and modulation of multidrug resistance. Euphorbia boissierana Prokh. is one of the 45 species growing in Georgia. A new lupane triterpene glycoside (1) was isolated from the MeOH extract of the aerial parts of E. boissierana. The structure of 1 was elucidated as 3-[(O-β-D-fucopyranosyl-(12)-β-D-glucopyranosyl)oxy] lup-20(29)-en-3β, 28-diol. Structure elucidation was accomplished through the extensive use of 1D- and 2D NMR experiments including 1H–1H (COSY) and 1H–13C (HSQC, HMBC) spectroscopy along with ESI-MS and HR-ESI-MS.This is the first report of the isolation of betulin glycoside from the genus Euphorbia.

Keywords

  • lupane,
  • Euphorbia boissierana Prokh,
  • Euphorbiaceae,
  • betulin,
  • triterpene glycoside
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