10.57647/pibm.2023.122319

Evaluation of the Performance of a Targeted Dermal Drug Delivery System: Magnetic Liposome/CoFe2O4/Ascorbic Acid Nanocarrier

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  • Mojdeh Khosravi Farahani1,
  • Parviz Aberoomand Azar1,
  • Mohammad Yousef*2,
  • Maryam Bikhof Torbati3,
  1. Department of Chemistry, SR.C., Islamic Azad University, Tehran, Iran
  2. Department of Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran
  3. Department of biology, YI.C., Islamic. Azad University, Tehran, Iran

Received: 2023-08-10

Revised: 2023-10-18

Accepted: 2023-10-22

Published in Issue 2023-12-30

Copyright (c) 2025 Mojdeh Khosravi Farahani, Parviz Aberoomand Azar, Mohammad Yousef, Maryam Bikhof Torbati (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Khosravi Farahani, M., Aberoomand Azar, P., Yousef, M., & Bikhof Torbati, M. (2023). Evaluation of the Performance of a Targeted Dermal Drug Delivery System: Magnetic Liposome/CoFe2O4/Ascorbic Acid Nanocarrier. Progress in Biomaterials, 12(4). https://doi.org/10.57647/pibm.2023.122319
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Abstract

The transdermal drug delivery system represents a non-invasive and proficient approach that facilitates gradual release of pharmaceuticals while targeting the specific site of action. This modality has the potential to enhance both the therapeutic effectiveness and safety profiles of medications, sustain consistent plasma concentrations of the drug, circumvent first-pass hepatic metabolism, and offers a method that is both convenient and devoid of pain. The use of nanocarriers such as magnetic liposome/CoFe2O4 is known for targeted drug delivery. In this study, magnetic liposome/CoFe2O4 nanocarrier was synthesized and characterized. Then, ascorbic acid with high antioxidant properties was encapsulated in magnetic liposome/CoFe2O4 nanocarrier. In the next step, the absorption of ascorbic acid was evaluated by various parameters such as ascorbic acid concentration (mg/L), pH, time (min), and weight percentage of CoFe2O4 (wt%) by experimental design and Box-Behnken method. Under optimal conditions, the highest absorption rate was obtained with a concentration of ascorbic acid 11.99 mg/L, a time of 27.43 minutes, pH=8.78 and a weight percentage of 13.85% CoFe2O4, equal to 99.99%. The nanoliposome/CoFe2O4/ascorbic acid formulation achieved controlled release, with <20% released in the first hour and 86% by 12 hours. Ex-vivo studies showed ~65% steady permeation compared to <60% burst permeation for free ascorbic acid in 8 hours, highlighting superior controlled delivery.

Keywords

  • Nanocarrier,
  • Magnetic liposome/CoFe2O4,
  • Ascorbic acid,
  • Optimization,
  • Release
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