OICC Press Progress in Biomaterials 2194-0517 12 4 2023 12 30 Evaluation of the Performance of a Targeted Dermal Drug Delivery System: Magnetic Liposome/CoFe2O4/Ascorbic Acid Nanocarrier 10.57647/pibm.2023.122319 EN Mojdeh Khosravi Farahani Department of Chemistry, SR.C., Islamic Azad University, Tehran, Iran Parviz Aberoomand Azar Department of Chemistry, SR.C., Islamic Azad University, Tehran, Iran Mohammad Yousef Department of Chemistry, TeMS.C., Islamic Azad University, Tehran, Iran Maryam Bikhof Torbati Department of biology, YI.C., Islamic. Azad University, Tehran, Iran Journal Article 2023 12 30 The transdermal drug delivery system represents a non-invasive and proficient approach that facilitates gradual release of pharmaceuticals while targeting the specific site of action. This modality has the potential to enhance both the therapeutic effectiveness and safety profiles of medications, sustain consistent plasma concentrations of the drug, circumvent first-pass hepatic metabolism, and offers a method that is both convenient and devoid of pain. The use of nanocarriers such as magnetic liposome/CoFe2O4 is known for targeted drug delivery. In this study, magnetic liposome/CoFe2O4 nanocarrier was synthesized and characterized. Then, ascorbic acid with high antioxidant properties was encapsulated in magnetic liposome/CoFe2O4 nanocarrier. In the next step, the absorption of ascorbic acid was evaluated by various parameters such as ascorbic acid concentration (mg/L), pH, time (min), and weight percentage of CoFe2O4 (wt%) by experimental design and Box-Behnken method. Under optimal conditions, the highest absorption rate was obtained with a concentration of ascorbic acid 11.99 mg/L, a time of 27.43 minutes, pH=8.78 and a weight percentage of 13.85% CoFe2O4, equal to 99.99%. The nanoliposome/CoFe2O4/ascorbic acid formulation achieved controlled release, with <20% released in the first hour and 86% by 12 hours. Ex-vivo studies showed ~65% steady permeation compared to <60% burst permeation for free ascorbic acid in 8 hours, highlighting superior controlled delivery.