10.1007/s40204-017-0071-0

Effect of electrospinning parameters on morphological properties of PVDF nanofibrous scaffolds

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  • Asma Sadat Motamedi1,
  • Hamid Mirzadeh*2,
  • Fereshteh Hajiesmaeilbaigi3,
  • Shadab Bagheri-Khoulenjani4,
  • MohammadAli Shokrgozar5,
  1. Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR
  2. Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR Polymer and Color Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR
  3. Optics and Quantum Technologies Research School, NSTRI, Tehran, IR
  4. Polymer and Color Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR
  5. National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, IR
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Published in Issue 2017-09-11

How to Cite

Motamedi, A. S., Mirzadeh, H., Hajiesmaeilbaigi, F., Bagheri-Khoulenjani, S., & Shokrgozar, M. (2017). Effect of electrospinning parameters on morphological properties of PVDF nanofibrous scaffolds. Progress in Biomaterials, 6(3 (September 2017). https://doi.org/10.1007/s40204-017-0071-0
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Abstract

Abstract Smart materials like piezoelectric polymers represent a new class of promising scaffold in neural tissue engineering. In the current study, the fabrication processing parameters of polyvinylidine fluoride (PVDF) nanofibrous scaffold are found as a potential scaffold with nanoscale morphology and microscale alignment. Electrospinning technique with the ability to mimic the structure and function of an extracellular matrix is a preferable method to customize the scaffold features. PVDF nanofibrous scaffolds were successfully fabricated by the electrospinning technique. The influence of PVDF solution concentration and other processing parameters like applied voltage, tip-to-collector distance, feeding rate, collector speed and the solvent were studied. The optimal parameters were 30 w/v% PVDF concentration, 15 kV applied voltage, 18 cm tip-to-collector distance, 0.5 ml/h feeding rate, 2500 rpm collector speed and N , N′ -dimethylacetamide/acetone as a solvent. The mean fiber diameter of the obtained scaffold was 352.9 ± 24 nm with uniform and aligned morphology. Finally, the cell viability and morphology of PC-12 cells on the optimum scaffold indicated the potential of PVDF nanofibrous scaffold for neural tissue engineering.

Keywords

  • Electrospinning,
  • Morphology,
  • PVDF nanofibrous scaffolds,
  • Processing parameters,
  • Tissue engineering
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