OICC Press Progress in Biomaterials 2194-0517 6 3 (September 2017) 2017 09 11 Effect of electrospinning parameters on morphological properties of PVDF nanofibrous scaffolds 10.1007/s40204-017-0071-0 EN Asma Sadat Motamedi Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR Hamid Mirzadeh Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR Polymer and Color Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR Fereshteh Hajiesmaeilbaigi Optics and Quantum Technologies Research School, NSTRI, Tehran, IR Shadab Bagheri-Khoulenjani Polymer and Color Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, IR MohammadAli Shokrgozar National Cell Bank of Iran, Pasteur Institute of Iran, Tehran, IR Journal Article 2017 09 11 Abstract Smart materials like piezoelectric polymers represent a new class of promising scaffold in neural tissue engineering. In the current study, the fabrication processing parameters of polyvinylidine fluoride (PVDF) nanofibrous scaffold are found as a potential scaffold with nanoscale morphology and microscale alignment. Electrospinning technique with the ability to mimic the structure and function of an extracellular matrix is a preferable method to customize the scaffold features. PVDF nanofibrous scaffolds were successfully fabricated by the electrospinning technique. The influence of PVDF solution concentration and other processing parameters like applied voltage, tip-to-collector distance, feeding rate, collector speed and the solvent were studied. The optimal parameters were 30 w/v% PVDF concentration, 15 kV applied voltage, 18 cm tip-to-collector distance, 0.5 ml/h feeding rate, 2500 rpm collector speed and N , N′ -dimethylacetamide/acetone as a solvent. The mean fiber diameter of the obtained scaffold was 352.9 ± 24 nm with uniform and aligned morphology. Finally, the cell viability and morphology of PC-12 cells on the optimum scaffold indicated the potential of PVDF nanofibrous scaffold for neural tissue engineering.