10.1007/s40204-014-0034-7

Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions

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  • Sai Santosh Babu Komakula1,
  • Snehal Raut1,
  • Nitin Pratap Verma2,
  • T. Avinash Raj1,
  • Mahesh J. Kumar1,
  • Arvind Sinha2,
  • Shashi Singh*1,
  1. CSIR-Centre for Cellular and Molecular Biology, Hyderabad, 500 007, IN
  2. CSIR-National Metallurgical Laboratory, Jamshedpur, 831 007, IN
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Published in Issue 2014-12-17

How to Cite

Komakula, S. S. B., Raut, S., Verma, N. P., Raj, T. A., Kumar, M. J., Sinha, A., & Singh, S. (2014). Assessment of injectable and cohesive nanohydroxyapatite composites for biological functions. Progress in Biomaterials, 4(1 (March 2015). https://doi.org/10.1007/s40204-014-0034-7
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Abstract

Abstract Pressing need for utilization of injectables/fillers in various forms of orthopaedic treatments/surgeries commands an equal demand for better graft material. Injectable bone graft material based on biomimetically synthesized nanohydroxyapatite was developed and subjected to ball milling for different times; three materials thus produced were evaluated for their biological properties. The three composites tested were found to have some difference in proliferation and differentiation on mesenchymal stem cells in cultures. In vivo studies were performed by implanting the graft materials with or without cells in the bone drill hole injury created in the femur of Wistar rats. Our studies show that the composites lead to well-healed injury site with normal histology without inflammation or fibrous tissue formation and bone deformity. This material needs to be tested on large animals for further ascertaining its applicability in clinical use.

Keywords

  • Biphasic apatite,
  • Bioactivity,
  • Osteointegrity,
  • Bone drill injury,
  • Histology
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