10.1007/s40204-021-00166-3

Gelatin-based instant gel-forming volatile spray for wound-dressing application

  • Mohammed Shahidul Islam1,
  • Jahid M. M. Islam2,
  • M Fizur Rahman3,
  • Mohammed Mizanur Rahman4,
  • Mubarak A. Khan*3,
  1. Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, 2000, BD Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, US
  2. Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD School of Science, Monash University Malaysia, Subang Jaya, Selangor, 47500, MY
  3. Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD
  4. Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, 2000, BD

Published in Issue 2021-09-20

How to Cite

Islam, M. S., Islam, J. M. M., Rahman, M. F., Rahman, M. M., & Khan, M. A. (2021). Gelatin-based instant gel-forming volatile spray for wound-dressing application. Progress in Biomaterials, 10(3 (September 2021). https://doi.org/10.1007/s40204-021-00166-3
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Abstract

Abstract This study was a successful endeavor to develop and investigate the suitability of a bioadhesive wound-healing gel based on gelatin for first-aid purposes. Polyethylene glycol (PEG) was used to prepare a denser phase of gelatin chains, and diethyl ether (DEE) was used to introduce high volatility to the solution. The prepared solution was stable in the storage container but rapidly formed (within 3 s) a protective and bioadhesive gel around the wound surface by being sprayed over the wound. Besides, it also suppressed pain and showed moderate antimicrobial activity against S. aureus . It was also found highly biocompatible and non-toxic. All the results revealed that the prepared solution could be an effective candidate for treating minor injuries or burn, especially for a first-aid purpose. Graphic abstract

Keywords

  • Healing gel,
  • Wound-healing spray,
  • Highly volatile gel,
  • Gelatin,
  • PEG

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