OICC Press Progress in Biomaterials 2194-0517 10 3 (September 2021) 2021 09 20 Gelatin-based instant gel-forming volatile spray for wound-dressing application 10.1007/s40204-021-00166-3 EN Mohammed Shahidul Islam Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, 2000, BD Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX, 79409, US Jahid M. M. Islam Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD School of Science, Monash University Malaysia, Subang Jaya, Selangor, 47500, MY M Fizur Rahman Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD Mohammed Mizanur Rahman Department of Applied Chemistry and Chemical Engineering, University of Dhaka, Dhaka, 2000, BD Mubarak A. Khan Institute of Radiation and Polymer Technology, Bangladesh Atomic Energy Commission, Dhaka, 1349, BD Journal Article 2021 09 20 Abstract This study was a successful endeavor to develop and investigate the suitability of a bioadhesive wound-healing gel based on gelatin for first-aid purposes. Polyethylene glycol (PEG) was used to prepare a denser phase of gelatin chains, and diethyl ether (DEE) was used to introduce high volatility to the solution. The prepared solution was stable in the storage container but rapidly formed (within 3 s) a protective and bioadhesive gel around the wound surface by being sprayed over the wound. Besides, it also suppressed pain and showed moderate antimicrobial activity against S. aureus . It was also found highly biocompatible and non-toxic. All the results revealed that the prepared solution could be an effective candidate for treating minor injuries or burn, especially for a first-aid purpose. Graphic abstract