Unripe grape juice (verjuice) as a natural catalyst was successfully applied to perform the one-pot reaction of aryl aldehydes, malononitrile, hydrazine hydrate and ethyl acetoacetate to synthesize pyranopyrazole derivatives in aqueous ethanol at room temperature in excellent yields. Furthermore, unripe grape juice catalyzed one-pot synthesis of hexahydroquinoline-3-carboxamide derivatives by the four-component reaction of arylaldehydes, dimedone, […]
1,3-Dibromo-5,5-dimethylhydantoin (DBH), as a cheap and commercially available reagent, is efficiently able to catalyze the synthesis of polyhydroquinoline derivatives and 12-aryl-8,9,10,12-tetrahydro[a] xanthene-11-ones via one-pot multi-component reactions. This novel synthetic method has the advantages of low cost and availability of the catalyst, short reaction times, high to excellent yields, simple and easy work-up and purification of […]
A simple and mild one-pot three-component reaction for the preparation 1,4-dihydropyridines has been developed from various aldehyde substrates, 1,3-dicarbonyl compounds (dimedone) and ammonium acetate (Hantzsch method) in the presence of a catalytic amount of phospho sulfonic acid (PSA) as an efficient and heterogeneous solid acid in EtOH at room temperature. Preparation of PSA is straightforward […]
Silica Vanadic Acid, SVA, (oxo-vanadium has been supported on silica) as a dual Lewis and Bronsted acid ability was prepared and efficiently catalyzed one-pot multi-component condensation of enolizable ketones or alkyl acetoacetates with aromatic aldehydes, acetonitrile and acetyl chloride. The described reaction was produced β-acetamido ketone or ester derivatives in high to excellent yields in […]
An efficient and eco-friendly method for the one-pot synthesis of 14-aryl-14H-dibenzo [a,i]xanthene-8,13-dione derivatives has been developed in the presence of Fe3O4@SiO2 core-shell nanoparticles. The multi-component reactions of 2-hydroxy-1,4-naphthoquinone, β-naphthol and aldehydes were efficiently catalyzed using novel nano-scale materials under reflux conditions. The present method offers several advantages such as environmentally benign, simple work-up, excellent yield […]
A simple and efficient procedure for the synthesis of 2-amino-3-cyanopyridines from aldehydes, ketones, malononitrile, and ammonium acetate via one-pot reaction is reported. Zinc zirconium phosphate (ZPZn) nanoparticles were used as a convenient and efficient catalyst for this multicomponent reaction (MCR) under solvent-free conditions, and fair to excellent yields were achieved. The catalyst was characterized by […]
Nanoporous sodium montmorillonite clay (Na+-MMT) was used as a support for the immobilization of 1-methyl-3-(trimethoxysilylpropyl)-imidazolium hydrogen sulfate (Na+-MMT-[pmim]HSO4). This catalyst showed excellent catalytic activity for the preparation of 2-amino-3-cyano-5-oxo-5,6,7,8-tetrahydro-4H-benzopyrans via three-component reactions between aldehydes, dimedone and malononitrile. The procedure gave the products in high yields within short reaction times. Also, this catalyst can be reused […]
A hydrophobic-bentonite catalyst (cetyltrimethyl ammonium bromide-bentonite) has been used as a very mild, neutral, eco-friendly, reusable, non-toxic, low-cost and easily available catalyst. It was prepared by replacing the exchangeable Na+ cations of a homoionic Na–bentonite with cetyltrimethyl ammonium bromide (CTMAB) cations. The catalyst was characterized by XRD, BET and SEM. The BET data and XRD […]
A bio-based magnetic nano-catalyst (Fe3O4@nano-dextrin/Ti(IV)) was synthesized via the preparation of Fe3O4@nano-dextrinas magnetic support and then its treatment with titanium tetrachloride (TiCl4). The properties of this catalyst were characterized by different kinds of techniques such as FT-IR, FESEM, TEM, ICP, XRF, VSM and TGA. As a first report, the catalytic activity of Fe3O4@nano-dextrin/Ti(IV) was investigated […]
In this research, we report a novel and green magnetic nanocatalyst; Fe3O4@SiO2@Vitamin C@Fe2O3 for clean synthesis of 3-amino-1-aryl-1H-benzo[f]chromene-2-carbonitriles with high-yield in water as solvent at room temperature. The nanocatalyst is stable under the synthetic conditions and it can be reused several times without considerable reduction in its catalytic activity. The catalyst structure was characterized by […]