n-Octyl-3-methylpipyridinium bromide ([OMePPy]+Br-): novel ionic liquid to promote green synthesis of polycyclic fused acridines

Authors

• Kobra Nikoofar * ¹
• Fatemeh Shahriyari ²

1. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran
2. Department of Chemistry, Faculty of Physics & Chemistry, Alzahra University, Tehran, Iran

Abstract

In this research, various polycyclic fused acridines were synthesized via the highly efficient and green one-step four-component reaction between isatins, dimedone, various amines, and dimethylacetylenedicarboxylates (DMAD/DEAD) in the presence of n-octyl-3-methylpipyridinium bromide ([OMePPy]⁺Br^–) as a newly prepared ionic liquid, in absolute green situations at room temperature under solvent-free conditions. The ionic liquid characterized by ¹H NMR, ¹³C NMR, GC-MASS, TGA/ DTG, EDX, and FESEM techniques. Utilizing an eco-friendly and simply synthesized ionic liquid, green and economic reaction media, and preparing a wide range of polycyclic fused acridines in good yields are some highlighted aspects of the reported protocol.

Keywords

• Ionic liquid
• Green chemistry
• Acridines
• Isatin
• Multi-component reaction (MCR)