Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities

Authors

• Ayoob Bazgir ¹
• Seyyedeh Cobra Azimi ²

1. Department of Chemistry, Shahid Beheshti University, P.O. Box 1983963113, Tehran, Iran.
2. Young Researchers and Elites Club, Rasht Branch, Islamic Azad University, Rasht, Iran.

Abstract

A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.

Keywords

• Ionic liquid
• Pyrimido[4
• 4-dione
• 5-d]pyrimidine-2
• 6-Amino-uracil
• Antibacterial activities