An efficient and convenient synthesis of quinazoline derivatives catalyzed by cyanuric chloride in water

Authors

• Mahshid Hossaini ¹
• Reza Heydari ¹
• Malek Taher Maghsoodlou ²

1. Department of Chemistry, the University of Sistan and Baluchestan, P.O. Box 98135-674, Zahedan, Iran.
2. Chemistry Department, Faculty of Science, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

In this work, an eco-friendly procedure for the preparation of 2,3-dihydroquinazoline-4(1H)-ones was developed by condensation reaction of benzylic and heterocyclic aldehydes with 2-aminobenzamide in the presence of catalytic amounts of cyanuric chloride (2,4,6-trichloro-1,3,5-triazin) as an available and inexpensive organo-catalyst under aqueous media as a green conditions. The new compounds characterized by IR, ¹HNMR, ¹³CNMR, Mass spectrometry, and CHN elemental analysis. Excellent yield, clean reaction media, simple workup and easy purification are advantages of this methodology.

Keywords

• Quinazoline
• Aldehyde. Water
• Green chemistry
• Cyanuric Chloride
• Organo-catalyst