P2O5-SiO2 (30% w/w) was found to be a useful catalyst for the synthesis of various 2-substituted aryl benzimidazoles under solvent-less and in solvent conditions from o-phenylenediamine and aldehydes. The products were directly recrystallized from methanol.
Ni2+ supported on hydroxyapatite-core@shell γ-Fe2O3 nanoparticles (γ-Fe2O3@HAp-Ni2+) was found to be a useful catalyst for the synthesis of benzimidazole derivatives from o-phenylenediamine and aldehydes under solvent and solvent-free conditions at 80 °C. This reaction affords the corresponding benzimidazole derivatives compared with the classical reactions this method consistently gives a high yield, easy magnetic separation, a […]
A water soluble, Bronsted acid, 5-sulfosalicylic acid as an efficient organocatalyst was used for the synthesis of physiologically active 2-substituted benzimidazole derivatives from o-phenylenediamine and aromatic aldehydes in ethanol at reflux condition. Cost-effectiveness, use of non-hazardous solvents, metal free and commercially available catalyst, single-step, environmentally friendly green method, high conversions, cleaner reaction profiles and simple […]