The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to be an efficient catalyst solvent for Henry reaction between nitromethane and isatin derivatives to provide 3-hydroxy-3-(nitromethyl)indolin-2-one under mild conditions. The ionic liquid amenable to successive recycling without appreciable decrease in activity. Synthesized compounds have been screened for their anti-diabetic activity.(The ionic liquid, N,N,N,N-tetramethylguanidiniumtriflate (TMGTf) was found to […]
An organosuperbase (N,N-dimethylbiguanide) immobilized on mesoporous and magnetically separable silica supports, was found for the first time, to act as a highly-stable, scalable and efficient heterogeneous catalyst for the Henry reaction under mild and neutral condition. Several factors such as catalyst amount, solvent and reaction time concerning the reactivity were also discussed. The procedure constitutes […]
The C-C bond formation is an important reaction in organic synthesis to obtain value-added intermediates. Therefore, in this paper an attempt has been made to accelerate the Henry reaction (C-C bond formation) between aryl aldehydes and nitromethane using less expensive whole cell biocatalyst, baker’s yeast (BY). The scope of the methodology was also tested for […]
