Ecofriendly synthesis of biscoumarin derivatives catalyzed by EDTA-modified magnetic animal bone meal nanoparticles in water

Abstract

In this research, magnetic animal bone meal nanoparticles functionalized with ethylenediaminetetraacetic acid (Fe₃O₄@ABM-EDTA) is reported as a green recyclable catalyst that catalyzed synthesis of biscoumarin derivatives in water. The catalyst was characterized by the Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), differential thermogravimetric (DTG), scanning electron microscope (SEM) and X-ray diffraction (XRD). This study has demonstrated that Fe₃O₄@ABM-EDTA can act as an efficient catalyst for synthesis of biscoumarines in the presence of water as solvent at reflux conditions. A wide range of aldehydes could react with 2-hydroxycoumarin and give biscoumarin derivatives in excellent yields. Moreover, Fe₃O₄@ABM-EDTA was magnetically recovered and reused for five cycles without any significant loss of efficiency.