OICC Press Iranian Journal of Catalysis 2345-4865 8 4 2024 02 03 Ecofriendly synthesis of biscoumarin derivatives catalyzed by EDTA-modified magnetic animal bone meal nanoparticles in water EN Ahmad Reza Momeni Department of Chemistry, Faculty of Science, Shahrekord University, Shahrekord, Iran. Sadegh Bakhtiar Faculty of Sciences, Shahrekord University, Shahrekord, Iran. Journal Article 2024 02 03 In this research, magnetic animal bone meal nanoparticles functionalized with ethylenediaminetetraacetic acid (Fe3O4@ABM-EDTA) is reported as a green recyclable catalyst that catalyzed synthesis of biscoumarin derivatives in water. The catalyst was characterized by the Fourier transform infrared spectroscopy (FT-IR), thermogravimetric analysis (TGA), differential thermogravimetric (DTG), scanning electron microscope (SEM) and X-ray diffraction (XRD). This study has demonstrated that Fe3O4@ABM-EDTA can act as an efficient catalyst for synthesis of biscoumarines in the presence of water as solvent at reflux conditions. A wide range of aldehydes could react with 2-hydroxycoumarin and give biscoumarin derivatives in excellent yields. Moreover, Fe3O4@ABM-EDTA was magnetically recovered and reused for five cycles without any significant loss of efficiency.