1,4-Disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2].2Cl) as an efï¬cient ionic catalyst for synthesis of phthalazine derivatives

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  • Farhad Shirini1,
  • Tahereh Ghauri Koodehi2,
  • Omid Goli-Jolodar2,
  • Omid Goli Jolodar1,
  1. Department of Chemistry, College of Science, University of Guilan, Rasht, Iran
  2. Department of Chemistry, College of Science, University of Guilan, Rasht, 41335, Iran.

Published in Issue 2024-02-03

How to Cite

Shirini, F., Ghauri Koodehi, T., Goli-Jolodar, O., & Goli Jolodar, O. (2024). 1,4-Disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2].2Cl) as an efficient ionic catalyst for synthesis of phthalazine derivatives. Iranian Journal of Catalysis, 7(4). https://oiccpress.com/ijc/article/view/3976

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Abstract

This article describe the applicability of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2].2Cl) as a green, versatile and Brönsted acidic ionic catalyst in the promotion of the synthesis of phthalazine derivatives via one-pot three component reaction between aromatic aldehydes, 1,3-diketone derivatives and phthalhydrazide under solvent-free reaction conditions. The main advantages of this method are: (1) simplicity of the procedure, (2) solvent-free conditions, (3) availability of the starting materials, (4) high reaction rates and excellent yields, (5) reusability of the catalyst and (6) no column chromatographic of the products.

Keywords

  • Brönsted acidic ionic catalyst,
  • Phthalazine derivatives,
  • Solvent-free conditions
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