OICC Press Iranian Journal of Catalysis 2345-4865 7 4 2024 02 03 1,4-Disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2].2Cl) as an efficient ionic catalyst for synthesis of phthalazine derivatives EN Farhad Shirini Department of Chemistry, College of Science, University of Guilan, Rasht, Iran 0000-0002-7204-5000 Tahereh Ghauri Koodehi Department of Chemistry, College of Science, University of Guilan, Rasht, 41335, Iran. Omid Goli-Jolodar Department of Chemistry, College of Science, University of Guilan, Rasht, 41335, Iran. Omid Goli Jolodar Department of Chemistry, College of Science, University of Guilan, Rasht, Iran Journal Article 2024 02 03 This article describe the applicability of 1,4-disulfopiperazine-1,4-diium chloride ([Piper-(SO3H)2].2Cl) as a green, versatile and Brönsted acidic ionic catalyst in the promotion of the synthesis of phthalazine derivatives via one-pot three component reaction between aromatic aldehydes, 1,3-diketone derivatives and phthalhydrazide under solvent-free reaction conditions. The main advantages of this method are: (1) simplicity of the procedure, (2) solvent-free conditions, (3) availability of the starting materials, (4) high reaction rates and excellent yields, (5) reusability of the catalyst and (6) no column chromatographic of the products.