Review: Current development on catalytic synthesis and pharmacological applications of 1,4-dihydropyridines

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  • Rajesh Kumar Singh1,
  • Ketki Sahore2,
  • Rekha Rana3,
  • Sahil Kumar4,
  • Deo Nandan Prasad1,
  1. Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Distt-Rupnagar, Punjab, India.
  2. KC Institute of Pharmaceutical Sciences, Pandoga, 177207, Distt-Una, Himachal Pradesh.
  3. DDM College of Pharmacy, Amb, 177203, Distt-Una, Himachal Pradesh.
  4. School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Distt-Baddi, 173205, Himachal Pradesh.

Published in Issue 2024-02-03

How to Cite

Singh, R. K., Sahore, K., Rana, R., Kumar, S., & Prasad, D. N. (2024). Review: Current development on catalytic synthesis and pharmacological applications of 1,4-dihydropyridines. Iranian Journal of Catalysis, 6(4). https://oiccpress.com/ijc/article/view/3928

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Abstract

1,4-Dihydropyridines (1,4-DHPs) are recognized as one of the most versatile pharmacophores present as central core in many pharmaceuticals. Low yield and harsh reaction conditions prompted the researchers for the development of new environmental- friendly methods for the synthesis of 1,4-DHPs. This review explored the development of various green chemistry approaches using new catalysts developed for constructing novel 1,4-dihydropyridine and its derivatives. The present review also encompasses the synthesis of some novel 1, 4-DHPs derivatives with novel pharmacological actions. We have restricted our review of synthesis and pharmacological actions of 1,4-DHPs from 2006 onwards.

Keywords

  • 4-Dihydropyridines,
  • Green chemistry,
  • Pharmacological actions,
  • Synthesis
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