OICC Press Iranian Journal of Catalysis 2345-4865 6 4 2024 02 03 Review: Current development on catalytic synthesis and pharmacological applications of 1,4-dihydropyridines EN Rajesh Kumar Singh Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Distt-Rupnagar, Punjab, India. Ketki Sahore KC Institute of Pharmaceutical Sciences, Pandoga, 177207, Distt-Una, Himachal Pradesh. Rekha Rana DDM College of Pharmacy, Amb, 177203, Distt-Una, Himachal Pradesh. Sahil Kumar School of Pharmacy and Emerging Sciences, Baddi University of Emerging Sciences and Technology, Distt-Baddi, 173205, Himachal Pradesh. Deo Nandan Prasad Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, 140126, Distt-Rupnagar, Punjab, India. Journal Article 2024 02 03 1,4-Dihydropyridines (1,4-DHPs) are recognized as one of the most versatile pharmacophores present as central core in many pharmaceuticals. Low yield and harsh reaction conditions prompted the researchers for the development of new environmental- friendly methods for the synthesis of 1,4-DHPs. This review explored the development of various green chemistry approaches using new catalysts developed for constructing novel 1,4-dihydropyridine and its derivatives. The present review also encompasses the synthesis of some novel 1, 4-DHPs derivatives with novel pharmacological actions. We have restricted our review of synthesis and pharmacological actions of 1,4-DHPs from 2006 onwards.