Fast one-pot synthesis of 1,8-dioxo-decahydroacridine derivatives using sulfonic acid functionalized LUS-1 and the study on their antimicrobial activities

HTML PDF
  • Zohreh Kheilkordi1,
  • Ghodsi Mohammadi Ziarani1,
  • Alireza Badiei2,
  • Ali Abolhasani Soorki3,
  1. Department of Chemistry, Alzahra University, Vanak Square, P.O. Box 1993893973, Tehran, Iran.
  2. School of Chemistry, College of Science, University of Tehran, Tehran, Iran.
  3. ACECR-Research Institute of Applied Sciences, Shahid Beheshti University, Tehran, Iran.

Published in Issue 2024-02-03

How to Cite

Kheilkordi, Z., Mohammadi Ziarani, G., Badiei, A., & Abolhasani Soorki, A. (2024). Fast one-pot synthesis of 1,8-dioxo-decahydroacridine derivatives using sulfonic acid functionalized LUS-1 and the study on their antimicrobial activities. Iranian Journal of Catalysis, 6(4). https://oiccpress.com/ijc/article/view/3925

HTML views: 13

PDF views: 192

Abstract

Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis.

Keywords

  • 8-dione,
  • Acridine-1,
  • Dimedone,
  • Nanoporous acid catalyst,
  • Sulfonic acid functionalized LUS-1
HTML PDF