OICC Press Iranian Journal of Catalysis 2345-4865 6 4 2024 02 03 Fast one-pot synthesis of 1,8-dioxo-decahydroacridine derivatives using sulfonic acid functionalized LUS-1 and the study on their antimicrobial activities EN Zohreh Kheilkordi Department of Chemistry, Alzahra University, Vanak Square, P.O. Box 1993893973, Tehran, Iran. Ghodsi Mohammadi Ziarani Department of Chemistry, Alzahra University, Vanak Square, P.O. Box 1993893973, Tehran, Iran. 0000-0001-5177-7889 Alireza Badiei School of Chemistry, College of Science, University of Tehran, Tehran, Iran. 0000-0002-6985-7497 Ali Abolhasani Soorki ACECR-Research Institute of Applied Sciences, Shahid Beheshti University, Tehran, Iran. Journal Article 2024 02 03 Mesoporous silica LUS-1 (Laval University Silica) was successfully functionalized by propyl sulfonic acid and was used as a recyclable catalyst for the synthesis of acridine-1,8-diones via a pseudo four component reaction of aromatic aldehydes, dimedone and ammonium acetate (or anilines). The excellent yields, short reaction time, simple work-up procedure, and environmentally friendly conditions are advantages of this method. All synthesized compounds were screened for antimicrobial and antifungal activities. Only compound 3e exhibited activity against Bacillus subtilis.