L-Proline catalyzed synthesis of Betti bases and biscoumarin derivatives

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  • Samaneh Zahiri1,
  • Masoud Mokhtary1,
  • Mogharab Torabi1,
  1. Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran

Published in Issue 2024-02-03

How to Cite

Zahiri, S., Mokhtary, M., & Torabi, M. (2024). L-Proline catalyzed synthesis of Betti bases and biscoumarin derivatives. Iranian Journal of Catalysis, 5(2). https://oiccpress.com/ijc/article/view/3851

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Abstract

The direct three component modified Mannich reaction via condensation of aldehydes, 2-naphthol or 2,7-naphthalendiol and piperidine to generate Betti bases has been carried out over L-proline (20 mol%) with high efficiency under solvent free conditions at 70 OC. Also, the reaction of aromatic aldehyde and 4-hydroxycoumarin in the presence of L-proline (20 mol%) in the ethanol under reflux conditions, lead to biscoumarin derivatives

Keywords

  • Betti base,
  • Biscoumarin,
  • L-proline,
  • Mannich type reaction,
  • Multicomponent reaction
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