OICC Press Iranian Journal of Catalysis 2345-4865 5 2 2024 02 03 L-Proline catalyzed synthesis of Betti bases and biscoumarin derivatives EN Samaneh Zahiri Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran Masoud Mokhtary Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran 0000-0003-3763-7139 Mogharab Torabi Department of Chemistry, Rasht Branch, Islamic Azad University, Rasht, Iran Journal Article 2024 02 03 The direct three component modified Mannich reaction via condensation of aldehydes, 2-naphthol or 2,7-naphthalendiol and piperidine to generate Betti bases has been carried out over L-proline (20 mol%) with high efficiency under solvent free conditions at 70 OC. Also, the reaction of aromatic aldehyde and 4-hydroxycoumarin in the presence of L-proline (20 mol%) in the ethanol under reflux conditions, lead to biscoumarin derivatives