Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities

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  • Ayoob Bazgir1,
  • Seyyedeh Cobra Azimi2,
  1. Department of Chemistry, Shahid Beheshti University, P.O. Box 1983963113, Tehran, Iran.
  2. Young Researchers and Elites Club, Rasht Branch, Islamic Azad University, Rasht, Iran.

Published in Issue 2024-02-03

How to Cite

Bazgir, A., & Azimi, S. C. (2024). Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities. Iranian Journal of Catalysis, 3(1). https://oiccpress.com/ijc/article/view/3748

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Abstract

A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.

Keywords

  • 4-dione,
  • 5-d]pyrimidine-2,
  • 6-Amino-uracil,
  • Antibacterial activities,
  • Ionic liquid,
  • Pyrimido[4
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