OICC Press Iranian Journal of Catalysis 2345-4865 3 1 2024 02 03 Facile one-pot synthesis of pyrimido[4,5-d]pyrimidine-2,4-diones in Ionic Liquid and study of their antibacterial activities EN Ayoob Bazgir Department of Chemistry, Shahid Beheshti University, P.O. Box 1983963113, Tehran, Iran. Seyyedeh Cobra Azimi Young Researchers and Elites Club, Rasht Branch, Islamic Azad University, Rasht, Iran. Journal Article 2024 02 03 A simple, novel, efficient and three-component procedure for the synthesis of pyrimido[4,5-d]pyrimidine-2,4-dione derivatives by the reaction of 6-amino-1,3-dimethyluracil, aldehyde and 2-benzylisothiourea hydrochloride promoted by ionic liquid 1-butyl-3-methylimidazolium bromide ([BMIm]Br) under solvent-free conditions is reported. The presented method is benefited from operational simplicity, simple workup and reusability of ionic liquid. These products were evaluated in vitro for their antibacterial activities.