Application of dimeric ortho-palladated complex of 2-methoxyphenethylamine in the Heck coupling reaction

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  • Abdol Hajipour1,
  • Fatemeh Abrishami2,
  1. Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA
  2. Department of Chemistry and Chemical Engineering, Malek-Ashtar University of Technology, Tehran, Iran.

Published in Issue 2024-02-03

How to Cite

Hajipour, A., & Abrishami, F. (2024). Application of dimeric ortho-palladated complex of 2-methoxyphenethylamine in the Heck coupling reaction. Iranian Journal of Catalysis, 2(3). https://oiccpress.com/ijc/article/view/3729

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Abstract

The application of the [Pd{C6H3(CH2CH2NH2)-4-OMe-5-κ2-C,N}(μ-Br)]2 complex of 2-methoxyphenethylamine in the Heck coupling reaction was considered under both conventional and microwave irradiation conditions, and their results were compared. This complex is an efficient, stable and non-sensitive to air and moisture catalyst for the vinylation of substituted aryl halides with different electronic properties. The cross-coupled products were produced in good to excellent yields using a catalytic amount of this complex in N-methyl-2-pyrrolidone (NMP) at 130 °C. In comparison to conventional heating conditions, the reactions under microwave irradiation gave higher yields in shorter reaction times.

Keywords

  • 2-Methoxyphenethylamine,
  • Catalyst,
  • Cyclopalladated complex,
  • Heck reaction,
  • Microwave irradiation
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