OICC Press Iranian Journal of Catalysis 2345-4865 2 3 2024 02 03 Application of dimeric ortho-palladated complex of 2-methoxyphenethylamine in the Heck coupling reaction EN Abdol Hajipour Department of Pharmacology, University of Wisconsin, Medical School, 1300 University Avenue, Madison, 53706-1532, WI, USA Fatemeh Abrishami Department of Chemistry and Chemical Engineering, Malek-Ashtar University of Technology, Tehran, Iran. Journal Article 2024 02 03 The application of the [Pd{C6H3(CH2CH2NH2)-4-OMe-5-κ2-C,N}(μ-Br)]2 complex of 2-methoxyphenethylamine in the Heck coupling reaction was considered under both conventional and microwave irradiation conditions, and their results were compared. This complex is an efficient, stable and non-sensitive to air and moisture catalyst for the vinylation of substituted aryl halides with different electronic properties. The cross-coupled products were produced in good to excellent yields using a catalytic amount of this complex in N-methyl-2-pyrrolidone (NMP) at 130 °C. In comparison to conventional heating conditions, the reactions under microwave irradiation gave higher yields in shorter reaction times.