Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat

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  • Md Rafiul Haque*1,
  • Md Afroz Ahmad2,
  • Kamran Ashraf3,
  • Md Habban Akhter4,
  • Mohammad Jameel5,
  • Abuzer Ali6,
  • Wasim Akhtar7,
  • Monika Dhaka4,
  • Kavita Rana8,
  1. School of Pharmacy, Al-Karim University, Bihar, India|School of Pharmaceutical Education and Research, Hamdard University, Hamdard Nagar, New Delhi 62, India
  2. Department of Prmhacology, Integral University, Lucknow (U.P), India
  3. Faculty of Pharmacy, University Teknologi MARA (UITM), Cawangan Selangor, Kampus Puncak Alam, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malasiya
  4. School of Pharmaceutical and population Health information (SoPPHI), DIT University, Dehradun 248009, India
  5. RRIUM, CCRUM Aligarh (UP), India
  6. Department of Pharmacognosy, College of Pharmacy, Taif University, P.O. box 21944, Saudi Arabia
  7. School of Pharmacy, Al-Karim University, Bihar, India
  8. Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida (UP), India

Revised: 2021-09-17

Accepted: 2021-12-11

Published in Issue 2021-12-01

How to Cite

Haque, M. R., Ahmad, M. A., Ashraf, K., Akhter, M. H., Jameel, M., Ali, A., Akhtar, W., Dhaka, M., & Rana, K. (2021). Arq ajwain protects nonalcoholic fatty liver disease on high-fat diet-induced obese rat. Trends in Phytochemical Research, 5(4), 209-221. https://oiccpress.com/tpr/article/view/11811

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Abstract

In the present study, we investigated the safety and therapeutic efficacy of arq ajwain (AA) against nonalcoholic fatty liver disease (NAFLD) on a high-fat diet (HFD) induced obese rat model. After 4 weeks of the treatment, AA (4 mL/kg, twice a day) and AA1 (7.75 mL/kg, twice a day) treatments reduced body weight, serum triglycerides (TG), total cholesterol (TG), glucose, insulin, leptin, pancreatic lipase activity and alanine aminotransferase (ALT) levels (p < 0.001). AA, AA1, and thymol (T) treatments also decreased lipids (TG and TC) levels and increased thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), and catalase (CAT) levels in hepatic tissue (p < 0.001). Moreover, treatment groups considerably reduced hepatic inflammation, steatosis, hepatocellular ballooning, and fibrosis. These results recommend that arq ajwain has a strong protective effect against NAFLD in HFD induced obese rat models.

Keywords

  • Ajwain,
  • insulin,
  • Oxidative stress,
  • Leptin,
  • Nonalcoholic fatty liver disease
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