Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand

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  • Kanchan Gairola1,
  • Shriya Gururani1,
  • Ravendra Kumar2,
  • Om Prakash2,
  • Sanjeev Agarwal1,
  • Shiv Dubey*1,
  1. Department of Biochemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India
  2. Department of Chemistry, G. B. Pant University of Agriculture and Technology, Pantnagar-263145, Uttarakhand, India

Revised: 2020-07-06

Accepted: 2021-03-07

Published in Issue 2021-03-01

How to Cite

Gairola, K., Gururani, S., Kumar, R., Prakash, O., Agarwal, S., & Dubey, S. (2021). Phytochemical composition, antioxidant, and anti-inflammatory activities of essential oil of Acmella uliginosa (Sw.) Cass. grown in North India Terai region of Uttarakhand. Trends in Phytochemical Research, 5(1), 44-52. https://oiccpress.com/tpr/article/view/11794

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Abstract

The plant Acmella uliginosa (Sw.) Cass. belonging to family Asteraceae was subjected to hydro distillation for essential oil extraction and was chemically analyzed by GC/MS for its phytochemical composition. Thirty-five compounds were identified comprising 88.1% of total essential oil composition. Limonene (12.2%) along with sesquisabinene isomer (7.3%) and caryophyllene oxide (5.9%) were the prominent compounds of the essential oil. In-vitro antioxidant activity of essential oil was investigated by DPPH free radical scavenging activity and metal chelating activity having IC50 value of 326.77 ± 5.34 μL and 14.853 ± 0.106 μL respectively whereas reducing power activity having RP50 value of 14.011 ± 0.0446 μL. The essential oil exhibited potent anti-inflammatory activity with IB50 value of 5.629 ± 0.0311 μL compared to standard Diclofenac sodium salt having IB50 value of 23.693 ± 0.306 μg/mL. The essential oil displayed exceedingly marked anti-inflammatory as well as antioxidant activities as compared to standard marketed drugs.

Keywords

  • Essential oil,
  • <i>Acmella uliginosa</i> (Sw.) Cass,
  • Limonene,
  • Anti-inflammatory activity,
  • antioxidant activity
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