A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae)

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  • Gervais Mouthe Happi*1,
  • Alexis Sylvain W. Mbobda2,
  • Marcel Frese3,
  • Simeon Fogue Kouam2,
  • Jean Claude Tchouankeu4,
  • Bruno Ndjakou Lenta2,
  • Norbert Sewald3,
  1. Department of Chemistry, Higher Teacher Training College, University of Bamenda, P.O Box 39, Bambili, Cameroon|Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
  2. Department of Chemistry, Higher Teacher Training College, University of Yaounde I, P. O. Box 47, Yaounde, Cameroon
  3. Organic and Bioorganic Chemistry, Faculty of Chemistry, Bielefeld University, D-33501 Bielefeld, Germany
  4. Department of Organic Chemistry, Faculty of Sciences, University of Yaounde I, P.O. Box 812, Yaounde, Cameroon

Revised: 2020-10-04

Accepted: 2021-03-07

Published in Issue 2021-03-01

How to Cite

Mouthe Happi, G., W. Mbobda, A. S., Frese, M., Fogue Kouam, S., Tchouankeu, J. C., Ndjakou Lenta, B., & Sewald, N. (2021). A new phenylpropanoid glucoside from Psorospermum tenuifolium Kotschy (Hypericaceae). Trends in Phytochemical Research, 5(1), 31-36. https://oiccpress.com/tpr/article/view/11792

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Abstract

A new phenylpropanoid glycoside named psorospermoside (1) possessing an allose unit was isolated from the Psorospermum tenuifolium Hook f. bark extract together with eleven known compounds. Their structures were elucidated using spectroscopic and spectrometric methods including 1D, 2D-NMR, and ESI-MS, as well as by comparison of their data with those reported in the literature. All the isolated compounds were assessed for their cytotoxicity effect on the human cervix carcinoma cell line KB3-1. Emodin (2) and its congener 2-geranylemodin (3) displayed significant cytotoxicity with IC50 values of 11.4 µM and 19.0µM, respectively. Furthermore, the chemotaxonomic significance of the isolated compounds was also discussed.

Keywords

  • 2-Geranylemodin,
  • Phenylpropanoid glucoside,
  • <i>Psorospermum tenuifolium</i>,
  • Emodin,
  • Cytotoxicity,
  • Psorospermoside
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