A mini-review on oxysporone

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  • Satyajit D. Sarker*1,
  • Lutfun Nahar1,
  • Tauhidur Rahman Nurunnabi2,
  • S.M. Mahbubur Rahman3,
  • Md. Hossain Sohrab4,
  • Md. Morsaline Billah3,
  • Fyaz M. D. Ismail1,
  • George P. Sharples1,
  1. Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom
  2. Medicinal Chemistry and Natural Products Research Group, School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, James Parsons Building, Byrom Street, Liverpool L3 3AF, United Kingdom | Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh
  3. Biotechnology and Genetic Engineering Discipline, Khulna University, Khulna, Bangladesh
  4. Pharmaceutical Sciences Research Division, BCSIR Laboratories, Dhaka

Revised: 2017-05-25

Accepted: 2017-06-02

Published in Issue 2017-06-01

How to Cite

Sarker, S. D., Nahar, L., Nurunnabi, T. R., Mahbubur Rahman, S., Sohrab, M. H., Billah, M. M., Ismail, F. M. D., & Sharples, G. P. (2017). A mini-review on oxysporone. Trends in Phytochemical Research, 1(2), 55-60. https://oiccpress.com/tpr/article/view/11685

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Abstract

Oxysporone, possessing a 4H-furo(2,3-b)pyran-2(3H)-one structure, is a fungal metabolite, first isolated from Fusarium oxysporum. Later, this compound was also reported from the fungal genera, Diplodia, Pestalotia and Pestalotiopsis. Oxysporone was patented as an antibiotic for the treatment of dysentery, and its phytotoxic property has been well-established. Interesting biological and chemical properties of oxysporone make this compound attractive for its potential biotechnological applications in agriculture, especially as a new agrochemical with a lower environmental impact. However, it requires further extensive bioactivity screening looking at beyond its established phytotoxicity and preliminary antifungal property. It has a simple chemical structure (C₇H₈O₄), and the hydroxyl group at C-4 provides options for synthesising numerous analogues by simply incorporating various functionalities at C-4, whilst keeping the main skeleton intact. This mini-review provides a critical overview on the occurrence, production, synthesis, structure elucidation and bioactivities of oxysporone.
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