10.57647/pibm.2024.132409

Development and Evaluation of Biocompatible Scaffolds for Chronic Wound Healing and Biomaterials: Incorporating Vancomycin and Graphene Oxide

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  • Alireza Jangi1,
  • Azadeh Asefnejad*1,
  • Shahrokh Shojaei2,
  • Hessam Rezaei1,
  • Mohammad Mohammadi1,
  • Sara Gholizadeh3,
  • Foad Iranmanesh4,
  1. Department of Biomedical Engineering, SR.C., Islamic Azad University, Tehran, Iran
  2. Department of Biomedical Engineering, CT.C., Islamic Azad University, Tehran, Iran
  3. Department of Aesthetic and Restorative Dentistry, Faculty of Dentistry, Isf.C, Islamic Azad University, Isfahan, Iran
  4. Department of Endodontic, School of Dentistry, Rafsanjan University of Medical Sciences, Rafsanjan, Iran

Published in Issue 2024-09-30

Copyright (c) 2024 Alireza Jangi, Azadeh Asefnejad, Shahrokh Shojaei, Hessam Rezaei, Mohammad Mohammadi, Sara Gholizadeh, Foad Iranmanesh (Author)

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Jangi, A., Asefnejad, A., Shojaei, S., Rezaei, H., Mohammadi, M., Gholizadeh, S., & Iranmanesh, F. (2024). Development and Evaluation of Biocompatible Scaffolds for Chronic Wound Healing and Biomaterials: Incorporating Vancomycin and Graphene Oxide. Progress in Biomaterials, 13(03). https://doi.org/10.57647/pibm.2024.132409
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Abstract

Chronic wounds represent a considerable challenge for healthcare systems, necessitating the identification of effective wound  dressings to facilitate healing. This study aimed to develop scaffolds utilizing biocompatible materials such as albumin and gelatin,  with the incorporation of vancomycin for its antibacterial properties and graphene oxide nanoparticles to enhance mechanical  strength. The scaffolds were fabricated through a freeze-drying technique and subsequently evaluated for morphology using  scanning electron microscopy (SEM), functional groups via Fourier-transform infrared spectroscopy (FTIR), and assessed for swelling, biodegradability, along with various mechanical, biological, and antibacterial properties. The release profile of vancomycin from the G.5%Al.3%Go scaffold exhibited a more controlled pattern compared to that of the G.5%Al.1%Go scaffold. Additionally, immersion of the scaffolds in phosphate-buffered saline for 30 minutes indicated that increased graphene oxide content  correlated with reduced swelling. Over a 15-day period, the degradation rate of the scaffolds revealed that the G.10%Al.3%Go scaffold degraded by up to 35%, while the G.5%Al.1%Go scaffold showed the lowest degradation rate at 18%. These results shows that the G.10%Al.3%Go scaffold may serve as a promising candidate for atopic treatment.

Keywords

  • Albumin,
  • Graphene oxide,
  • Biomaterials,
  • Vancomycin,
  • Freeze-drying,
  • Chemical stability
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