10.1007/s40204-020-00140-5

PEGylated curcumin-loaded nanofibrous mats with controlled burst release through bead knot-on-spring design

  • Mahdi Saeed*1,
  • Hamid Mirzadeh2,
  • Mojgan Zandi3,
  • Jalal Barzin3,
  1. Soft Tissue Engineering Research Center, Tissue Engineering and Regenerative Medicine Institute, Central Tehran Branch, Islamic Azad University, Tehran, IR Department of Biomedical Engineering, Central Tehran Branch, Islamic Azad University, Tehran, IR
  2. Department of Polymer Engineering, Amirkabir University of Technology, Tehran, IR
  3. Department of Biomaterials, Iran Polymer and Petrochemical Institute, Tehran, IR

Published in Issue 2020-10-18

How to Cite

Saeed, M., Mirzadeh, H., Zandi, M., & Barzin, J. (2020). PEGylated curcumin-loaded nanofibrous mats with controlled burst release through bead knot-on-spring design. Progress in Biomaterials, 9(4 (December 2020). https://doi.org/10.1007/s40204-020-00140-5
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Abstract

Abstract APEGylatedcurcumin (PCU) loaded electrospuns based on poly(ε-caprolactone) (PCL) andpolyvinyl alcohol (PVA) were fabricated for wound dressing applications. The main reason for this wound dressing design is antibacterialactivity enhancement, and wound exudates management. PEGylation increases curcuminsantibacterial properties and PVA can help exudates management. For optimal wound dressing, first, response surface methodology (RSM) was applied to optimize the electrospinning parameters to achieve appropriate nanofibrous mats. Then a three-layer electrospun was designed by considering the water absorbability, PCU release profile as well as antibacterial and biocompatibility of the final wound dressing. The burst release in controlled release systems could be evaluated for prevention of the higher initial drug release and control the effective life time. The PCU release results illustrated that the bead knot plays a positive role in controlling the release profile andby increase in the number of beads per unit area from 3000 to 9000 mm −2 ,the PCU burst release will be reduced; Also in vitro studies show that optimized three-layer dressing based on PCL/PVA/PCU can support water vapour transmission rate in optimal range and also absorb more than three times exudates in comparison with mono-layerdressing. Antibacterial tests show that the electrospun wound dressing containing 5% PCU exhibits100% antibacterial activityas well as cell viability level within an acceptable range.

Keywords

  • Electrospun nanofibrous,
  • Bead knot-on-spring,
  • Three-layered wound dressing,
  • Pegylatedcurcumin,
  • Burst release

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