10.1007/s40204-020-00136-1

Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing

XML HTML PDF
  • Beata Kaczmarek1,
  • Olha Mazur1,
  • Oliwia Miłek2,
  • Marta Michalska-Sionkowska3,
  • Anna M. Osyczka2,
  • Konrad Kleszczyński*4,
  1. Department of Biomaterials and Cosmetics Chemistry, Faculty of Chemistry, Nicolaus Copernicus University, Toruń, 87-100, PL
  2. Department of Biology and Cell Imaging, Faculty of Biology, Institute of Zoology and Biomedical Research, Jagiellonian University, Kraków, 30-387, PL
  3. Department of Environmental Microbiology and Biotechnology, Faculty of Biology and Environmental Protection, Nicolaus Copernicus University, Toruń, 87-100, PL
  4. Department of Dermatology, University of Münster, Münster, 48149, DE
Cover Image

Published in Issue 2020-09-20

How to Cite

Kaczmarek, B., Mazur, O., Miłek, O., Michalska-Sionkowska, M., Osyczka, A. M., & Kleszczyński, K. (2020). Development of tannic acid-enriched materials modified by poly(ethylene glycol) for potential applications as wound dressing. Progress in Biomaterials, 9(3 (September 2020). https://doi.org/10.1007/s40204-020-00136-1
Crossref
Scopus
Google Scholar
Europe PMC

Abstract

Abstract The interests in the biomedical impact of tannic acid (TA) targeting production of various types of biomaterials, such as digital microfluids, chemical sensors, wound dressings, or bioimplants constantly increase. Despite the significant disadvantage of materials obtained from natural-based compounds and their low stability and fragility, therefore, there is an imperative need to improve materials properties by addition of stabilizing formulas. In this study, we performed assessments of thin films over TA proposed as a cross-linker to be used in combination with polymeric matrix based on chitosan (CTS), i.e. CTS/TA at 80:20 or CTS/TA at 50:50 and poly(ethylene glycol) (PEG) at the concentration of 10% or 20%. We evaluated their mechanical parameters as well as the cytotoxicity assay for human bone marrow mesenchymal stem cells, human melanotic melanoma (MNT-1), and human osteosarcoma (Saos-2). The results revealed significant differences in dose-dependent of PEG regarding the maximum tensile strength ( σ max ) or impact on the metabolic activity of tissue culture plastic. We observed that PEG improved mechanical parameters prominently, decreased the hemolysis rate, and did not affect cell viability negatively. Enclosed data, confirmed also by our previous reports, will undoubtedly pave the path for the future application of tannic acid-based biomaterials to treat wound healing.

Keywords

  • Tannic acid,
  • Poly(ethylene glycol),
  • Regeneration,
  • Wound dressing,
  • Proliferation
HTML PDF

References

  1. Bassyouni M, Javaid U, Hasan SW (2017) Bio-based hybrid polymer composites: a sustainable high performance material. In: Hybrid polymer composite materials, pp 23–70
  2. Buono et al. (2018) Clicking biobased polyphenols: a sustainable platform for aromatic polymeric materials (pp. 2472-2491) https://doi.org/10.1002/cssc.201800595
  3. Chang et al. (2016) PEG–chitosan hydrogel with tunable stiffness for study of drug response of breast cancer cells https://doi.org/10.3390/polym8040112
  4. Cirillo G, Curcio M, Spataro T, Picci N, Restuccia D, Iemma F, Spizzirri UG (2018) Antioxidant polymers for food packaging. In: Academic Press (ed) Food Packaging and Preservation, Handbook of Food Bioengineering, pp 213–238.
  5. de Dicastillo et al. (2016) Antioxidant films based on cross-linked methyl cellulose and native Chilean berry for food packaging applications (pp. 1052-1060) https://doi.org/10.1016/j.carbpol.2015.10.013
  6. de Lima et al. (2018) Mucoadhesive chitosan-coated PLGA nanoparticles for oral delivery of ferulic acid (pp. 993-1002) https://doi.org/10.1080/21691401.2018.1477788
  7. Deible et al. (1999) Molecular barriers to biomaterial thrombosis by modification of surface proteins with polyethylene glycol (pp. 101-109) https://doi.org/10.1016/S0142-9612(98)00001-5
  8. Faradilla et al. (2019) Effect of polyethylene glycol (PEG) molecular weight and nanofillers on the properties of banana pseudostem nanocellulose films (pp. 330-339) https://doi.org/10.1016/j.carbpol.2018.10.049
  9. Fu and Kao (2009) Drug release kinetics and transport mechanisms from semi-interpenetrating networks of gelatin and poly(ethylene glycol) diacrylate (pp. 2115-2124) https://doi.org/10.1007/s11095-009-9923-1
  10. Gentile et al. (2017) Multilayer nanoscale encapsulation of biofunctional peptides to enhance bone tissue regeneration in vivo https://doi.org/10.1002/adhm.201601182
  11. Jayaprakash et al. (2015) Antibacterial activity of silver nanoparticles synthesized from serine mater (pp. 316-322) https://doi.org/10.1016/j.msec.2015.01.012
  12. Kaczmarek et al. (2017) The comparison of physic-chemical properties of chitosan/collagen/hyaluronic acid composites with nano-hydroxyapatite cross-linked by dialdehyde starch and tannic acid (pp. 171-176) https://doi.org/10.1016/j.polymertesting.2017.06.027
  13. Kaczmarek et al. (2018) In vivo studies of novel scaffolds with tannic acid addition (pp. 26-30) https://doi.org/10.1016/j.polymdegradstab.2018.10.018
  14. Kaczmarek et al. (2019) The characterization of thin films based on chitosan and tannic acid mixture for potential applications as wound dressings https://doi.org/10.1016/j.polymertesting.2019.106007
  15. Kaczmarek et al. (2019) The film-forming properties of chitosan with tannic acid addition (pp. 22-24) https://doi.org/10.1016/j.matlet.2019.02.090
  16. Kadzinska et al. (2019) An overview of fruit and vegetable edible packaging materials (pp. 483-495) https://doi.org/10.1002/pts.2440
  17. Kameneva et al. (2003) Polyethylene glycol additives reduce hemolysis in red blood cell suspensions exposed to mechanical stress (pp. 537-542) https://doi.org/10.1097/01.MAT.0000084176.30221.CF
  18. Kamoun et al. (2017) A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings (pp. 217-233) https://doi.org/10.1016/j.jare.2017.01.005
  19. Kang et al. (2011) A biofunctionalization scheme for neural interfaces using polydopamine polymer (pp. 6374-6380) https://doi.org/10.1016/j.biomaterials.2011.05.028
  20. Karaseva et al. (2019) New biosourced flame retardant agents based on gallic and ellagic acids for epoxy resins https://doi.org/10.3390/molecules24234305
  21. Kozłowska et al. (2018) Preparation and characterization of collagen/chitosan poly(ethylene glycol)/nanohydroxyapatite composite scaffolds (pp. 799-803) https://doi.org/10.1002/pat.4506
  22. Lee et al. (2018) Development of a tannic acid cross-linking process for obtaining 3D porous cell-laden collagen structure (pp. 497-503) https://doi.org/10.1016/j.ijbiomac.2017.10.105
  23. Lewandowska et al. (2016) The miscibility of collagen/hyaluronic acid/chitosan blends investigated in dilute solutions and solids (pp. 726-730) https://doi.org/10.1016/j.molliq.2016.05.009
  24. Lima et al. (2018) Physical characterization and modeling of chitosan/peg blends for injectable scaffolds (pp. 238-249) https://doi.org/10.1016/j.carbpol.2018.02.045
  25. Mao et al. (2005) Synthesis, characterization and cytotoxicity of poly(ethylene glycol)-graft-trimethyl chitosan block copolymers (pp. 6343-6356) https://doi.org/10.1016/j.biomaterials.2005.03.036
  26. Michalska-Sionkowska et al. (2018) Antimicrobial activity of new materials based on the blends of collagen/chitosan/hyaluronic acid with gentamicin sulfate addition (pp. 103-108) https://doi.org/10.1016/j.msec.2018.01.005
  27. Morgado et al. (2015) Asymmetric membranes as ideal wound dressings: an overview on production methods, structure, properties and performance relationship (pp. 139-151) https://doi.org/10.1016/j.memsci.2015.04.064
  28. Oda et al. (2014) Effects of polyethylene glycol administration and bone marrow stromal cell transplantation therapy in spinal cord injury mice (pp. 415-421) https://doi.org/10.1292/jvms.13-0167
  29. Pandit P, Nadathur GT, Maiti S, Regubalan B (2018) Functionality and properties of bio-based materials. In: Bio-based materials for food packaging, pp 81–103
  30. Phaechamud et al. (2016) Gentamicin sulfate-loaded porous natural rubber films for wound dressing (pp. 634-644) https://doi.org/10.1016/j.ijbiomac.2016.01.040
  31. Pires et al. (2018) Towards wound dressings with improved properties: effects of poly(dimethylsiloxane) on chitosan-alginate films loaded with thymol and beta-carotene (pp. 595-605) https://doi.org/10.1016/j.msec.2018.08.005
  32. Sadhasivam et al. (2015) Transdermal patches of chitosan nanoparticles for insulin delivery (pp. 84-88)
  33. Sagnella and Mai-Ngam (2005) Chitosan based surfactants polymers designed to improve blood compatibility on biomaterials (pp. 147-155) https://doi.org/10.1016/j.colsurfb.2004.07.001
  34. Sarvothaman et al. (2015) Dynamic fluoroalkyl polyethylene glycol co-polymers: a new strategy for reducing protein adhesion in lab-on-a-chip devices (pp. 506-515) https://doi.org/10.1002/adfm.201402218
  35. Shih et al. (2011) Synthesis and evaluation of poly(hexamethylene-urethane) and peg-poly(hexamethylene-urethane) and their cholesteryl oleyl carbonate composites for human blood biocompatibility (pp. 8181-8197) https://doi.org/10.3390/molecules16108181
  36. Sun et al. (2018) Effect of the molecular weight of polyethylene glycol (PEG) on the properties of chitosan–PEG–poly(N-isopropylacrylamide) hydrogels (pp. 2865-2872) https://doi.org/10.1007/s10856-008-3410-9
  37. Sun et al. (2019) Preparation, characterizations and properties of sodium alginate grafted acrylonitrile/polyethylene glycol electrospun nanofibers (pp. 420-425) https://doi.org/10.1016/j.ijbiomac.2019.06.185
  38. Uchida et al. (2005) Reduced platelet adhesion to titanium metal coated with apatite, albumin-apatite composite or laminin–apatite composite (pp. 6924-6931) https://doi.org/10.1016/j.biomaterials.2005.04.066
  39. Weber et al. (2018) Blood-contacting biomaterials: in vitro evaluation of the hemocompatibility https://doi.org/10.3389/fbioe.2018.00099
  40. Xie et al. (2018) Naturally occurring gallic acid derived multifunctional porous polymers for highly efficient CO2 conversion and I2 capture (pp. 4655-4661) https://doi.org/10.1039/C8GC02685H
  41. Xu et al. (2016) Controlled water vapor transmission rate promotes wound-healing via wound re-epithelialization and contraction enhancement https://doi.org/10.1038/srep24596
  42. Zhou et al. (2011) Biocompatibility and characteristics of injectable chitosan-based thermosensitive hydrogel for drug delivery (pp. 1643-1651) https://doi.org/10.1016/j.carbpol.2010.10.022