10.1007/s40204-020-00130-7

Fabrication of a novel hydroxyapatite/polyether ether ketone surface nanocomposite via friction stir processing for orthopedic and dental applications

  1. Department of Endodontic, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IR
  2. School of Chemical and Energy Engineering, University Teknologi Malaysia, Skudai, Johor, 81310, MY
  3. Department of Mechanical Engineering, Faculty of Energy, Kermanshah University of Technology, Kermanshah, IR
  4. Department of Oral and Maxillofacial Medicine, School of Dentistry, Kermanshah University of Medical Sciences, Kermanshah, IR Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, IR

Published in Issue 2020-05-03

How to Cite

Almasi, D., Lau, W. J., Rasaee, S., Sharifi, R., & Mozaffari, H. R. (2020). Fabrication of a novel hydroxyapatite/polyether ether ketone surface nanocomposite via friction stir processing for orthopedic and dental applications. Progress in Biomaterials, 9(1-2 (June 2020). https://doi.org/10.1007/s40204-020-00130-7

Abstract

Abstract There is increasing interest in the use of polyether ether ketone (PEEK) for orthopedic and dental implant applications due to its elastic modulus (close to that of bone), biocompatibility and radiolucent properties. However, PEEK is still categorized as bioinert owing to its low integration with surrounding tissues. Methods such as depositing hydroxyapatite (HA) onto the PEEK surface could increase its bioactivity. However, depositing HA without damaging the PEEK substrate is still required further investigation. Friction stir processing is a solid-state processing method that is widely used for composite substrate fabrication. In this study, a pinless tool was used to fabricate a HA/PEEK surface nanocomposite for orthopedic and dental applications. Microscopical images of the modified substrate confirmed homogenous distribution of the HA on the surface of the PEEK. The resultant HA/PEEK surface nanocomposites demonstrated improved surface hydrophilicity coupled with better apatite formation capacity (as shown in the simulated body fluid) in comparison to the pristine PEEK, making the newly developed material more suitable for biomedical application. This surface deposition method that is carried out at low temperature would not damage the PEEK substrate and thus could be a good alternative for existing commercial methods for PEEK surface modification.

Keywords

  • PEEK,
  • Hydroxyapatite,
  • FSP,
  • Nanocomposite,
  • Pin-less tool,
  • Bioactivity

References

  1. Ahmed et al. (2018) Investigation and development of friction stir welding process for unreinforced polyphenylene sulfide and reinforced polyetheretherketone https://doi.org/10.1177/0892705718785676
  2. Alla et al. (2011) Surface roughness of implants: a review (pp. 112-118)
  3. Almasi et al. (2016) Preparation methods for improving PEEK’s bioactivity for orthopedic and dental application: a review https://doi.org/10.1155/2016/8202653
  4. Aravind and Sangeetha (2015) Characterization and in vitro studies of sulfonated polyether ether ketone/polyether sulfone/nano hydroxyapatite composite (pp. 220-227) https://doi.org/10.1080/00914037.2014.936594
  5. Arima and Iwata (2007) Effect of wettability and surface functional groups on protein adsorption and cell adhesion using well-defined mixed self-assembled monolayers (pp. 3074-3082) https://doi.org/10.1016/j.biomaterials.2007.03.013
  6. Bakar et al. (2003) Tensile properties and microstructural analysis of spheroidized hydroxyapatite–poly (etheretherketone) biocomposites (pp. 55-63) https://doi.org/10.1016/S0921-5093(02)00289-7
  7. Barletta et al. (2011) Scratch response of high-performance thermoset and thermoplastic powders deposited by the electrostatic spray and ‘hot dipping’fluidised bed coating methods: the role of the contact condition (pp. 5186-5198) https://doi.org/10.1016/j.surfcoat.2011.05.032
  8. Chou et al. (1999) Effects of hydroxylapatite coating crystallinity on biosolubility, cell attachment efficiency and proliferation in vitro (pp. 977-985) https://doi.org/10.1016/S0142-9612(98)00254-3
  9. Costa et al. (2014) Surface enhancement of cold work tool steels by friction stir processing with a pinless tool (pp. 214-220) https://doi.org/10.1016/j.apsusc.2014.01.094
  10. Farnoush et al. (2013) Tribological and corrosion behavior of friction stir processed Ti-CaP nanocomposites in simulated body fluid solution (pp. 90-97) https://doi.org/10.1016/j.jmbbm.2012.12.001
  11. Farnoush et al. (2013) An innovative fabrication of nano-HA coatings on Ti-CaP nanocomposite layer using a combination of friction stir processing and electrophoretic deposition (pp. 1477-1483) https://doi.org/10.1016/j.ceramint.2012.07.092
  12. Filiaggi et al. (1991) Student research award in the undergraduate, Master candidate category, or health science degree candidate category, 17th annual meeting of the society for biomaterials, scottsdale, AZ may 1–5, 1991. Characterization of the interface in the plasma-sprayed HA coating/Ti-6Al-4V implant system (pp. 1211-1229) https://doi.org/10.1002/jbm.820251004
  13. Gan et al. (2010) Friction stir processing of particle reinforced composite (pp. 329-350) https://doi.org/10.3390/ma3010329
  14. Ha et al. (1994) Plasma-sprayed hydroxylapatite coating on carbon fibre reinforced thermoplastic composite materials (pp. 481-484) https://doi.org/10.1007/BF00058987
  15. Ha et al. (1997) Topographical characterization and microstructural interface analysis of vacuum-plasma-sprayed titanium and hydroxyapatite coatings on carbon fibre-reinforced poly(etheretherketone) (pp. 891-896) https://doi.org/10.1023/A:1018562023599
  16. Hahn (2013) Osteoconductive hydroxyapatite coated PEEK for spinal fusion surgery (pp. 6-11) https://doi.org/10.1016/j.apsusc.2013.05.073
  17. Huang et al. (2004) In vitro assessment of the biological response to nano-sized hydroxyapatite (pp. 441-445) https://doi.org/10.1023/B:JMSM.0000021117.67205.cf
  18. Kokubo (1998) Apatite formation on surfaces of ceramics, metals and polymers in body environment (pp. 2519-2527) https://doi.org/10.1016/S1359-6454(98)80036-0
  19. Kokubo and Takadama (2006) How useful is SBF in predicting in vivo bone bioactivity? (pp. 2907-2915) https://doi.org/10.1016/j.biomaterials.2006.01.017
  20. Landi et al. (2000) Densification behaviour and mechanisms of synthetic hydroxyapatites (pp. 2377-2387) https://doi.org/10.1016/S0955-2219(00)00154-0
  21. Lee (2013) In vitro and in vivo evaluation of the bioactivity of hydroxyapatite-coated polyetheretherketone biocomposites created by cold spray technology (pp. 6177-6187) https://doi.org/10.1016/j.actbio.2012.11.030
  22. Liu (2009) Micro-scratch study of a magnetron-sputtered Zr-based metallic-glass film (pp. 3480-3484) https://doi.org/10.1016/j.surfcoat.2009.05.017
  23. Mendonça et al. (2008) Advancing dental implant surface technology—from micron-to nanotopography (pp. 3822-3835) https://doi.org/10.1016/j.biomaterials.2008.05.012
  24. Morishige et al. (2008) Microstructural modification of cast Mg alloys by friction stir processing (pp. 109-113) https://doi.org/10.1179/136404608X361774
  25. Müller et al. (2014) The effect of particle agglomeration on the formation of a surface-connected compartment induced by hydroxyapatite nanoparticles in human monocyte-derived macrophages (pp. 1074-1088) https://doi.org/10.1016/j.biomaterials.2013.10.041
  26. Pan YS, Wang J, Pan CL Research on biological properties of PEEK based composites. In: Applied mechanics and materials, 2013. Trans Tech Publ, pp 3–7
  27. Paoletti et al. (2016) Analysis of forces and temperatures in friction spot stir welding of thermoplastic polymers (pp. 1395-1407) https://doi.org/10.1007/s00170-015-7669-y
  28. Prasad and Raghava (2012) Fsw of polypropylene reinforced with Al2O3 nano composites, effect on mechanical and microstructural properties (pp. 288-296)
  29. Rabiei and Sandukas (2013) Processing and evaluation of bioactive coatings on polymeric implants (pp. 2621-2629) https://doi.org/10.1002/jbm.a.34557
  30. Radin and Ducheyne (1992) Plasma spraying induced changes of calcium phosphate ceramic characteristics and the effect onin vitro stability (pp. 33-42) https://doi.org/10.1007/BF00702942
  31. Ratna Sunil et al. (2014) Friction stir processing of magnesium–nanohydroxyapatite composites with controlled in vitro degradation behavior (pp. 315-324) https://doi.org/10.1016/j.msec.2014.03.004
  32. Ratna Sunil et al. (2014) Nano-hydroxyapatite reinforced AZ31 magnesium alloy by friction stir processing: a solid state processing for biodegradable metal matrix composites (pp. 975-988) https://doi.org/10.1007/s10856-013-5127-7
  33. Roeder et al. (2008) Hydroxyapatite-reinforced polymer biocomposites for synthetic bone substitutes (pp. 38-45) https://doi.org/10.1007/s11837-008-0030-2
  34. Shen et al. (2014) A review of hydroxyapatite microstructure regulation with hydrothermal method (pp. 03006-03010)
  35. Shi et al. (2009) Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells (pp. 338-345) https://doi.org/10.1016/j.actbio.2008.07.023
  36. Stanford (2008) Surface modifications of dental implants
  37. Strnad et al. (2000) Effect of plasma-sprayed hydroxyapatite coating on the osteoconductivity of commercially pure titanium implants (pp. 483-490)
  38. Wang et al. (2010) Mechanical properties and microstructure of polyetheretherketone–hydroxyapatite nanocomposite materials (pp. 2201-2204) https://doi.org/10.1016/j.matlet.2010.06.067
  39. Wang et al. (2011) Characterization of polyetheretherketone–hydroxyapatite nanocomposite materials (pp. 3689-3696) https://doi.org/10.1016/j.msea.2011.01.064
  40. Wang (2014) Polyetheretherketone/nano-fluorohydroxyapatite composite with antimicrobial activity and osseointegration properties (pp. 6758-6775) https://doi.org/10.1016/j.biomaterials.2014.04.085
  41. Wu et al. (2012) Nano-TiO2/PEEK bioactive composite as a bone substitute material: in vitro and in vivo studies
  42. Xu S, Ma X, Wen H, Tang G, Li C (2014) Effect of annealing on the mechanical and scratch properties of BCN films obtained by magnetron sputtering deposition. Appl Surf Sci
  43. Xue et al. (2004) In vivo evaluation of plasma sprayed hydroxyapatite coatings having different crystallinity (pp. 415-421) https://doi.org/10.1016/S0142-9612(03)00545-3
  44. Zhang et al. (2006) Microwave sintering of poly-ether-ether-ketone (PEEK) based coatings deposited on metallic substrate (pp. 621-624) https://doi.org/10.1016/j.scriptamat.2006.06.010