10.1007/s40204-020-00128-1

Amphiphilic dextran-vinyl laurate-based nanoparticles: formation, characterization, encapsulation, and cytotoxicity on human intestinal cell line

  • Pattaramon Kraisomdet1,
  • Thiraya Pratess1,
  • Pawida Na Nakorn1,
  • Pinyapat Sangkaew1,
  • Ariya Naneto1,
  • Pranee Inprakon1,
  • Watanalai Panbangred2,
  • Nisa Patikarnmonthon*2,
  1. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, TH
  2. Department of Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, TH Mahidol University-Osaka University: Collaborative Research Center for Bioscience and Biotechnology, Faculty of Science, Mahidol University, Bangkok, 10400, TH

Published in Issue 2020-02-18

How to Cite

Kraisomdet, P., Pratess, T., Na Nakorn, P., Sangkaew, P., Naneto, A., Inprakon, P., Panbangred, W., & Patikarnmonthon, N. (2020). Amphiphilic dextran-vinyl laurate-based nanoparticles: formation, characterization, encapsulation, and cytotoxicity on human intestinal cell line. Progress in Biomaterials, 9(1-2 (June 2020). https://doi.org/10.1007/s40204-020-00128-1
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Abstract

Abstract Dextran has been the model material for the therapeutic applications owing to its biodegradable and biocompatible properties, and the ability to be functionalized in variety of ways. In this study, the amphiphilic dextran was successfully synthesized through lipase-catalyzed transesterification between dextran and vinyl laurate. In aqueous solution, the produced dextran ester could self-assemble into spherical nanoparticles (“Dex-L NPs”) with approximately 200-nm diameter, and could incorporate porcine placenta hydrolysate with 60% encapsulation efficiency. Furthermore, Dex-L NPs exhibited low cytotoxic effects on human intestinal cell line and, thus, were potentially safe for oral administration. Taken together, the findings illustrate the potential of the newly developed nanoparticles to serve as an efficient and safe drug delivery system.

Keywords

  • Dextran,
  • Vinyl laurate,
  • Nanoparticles,
  • Drug delivery,
  • Encapsulation,
  • Cytotoxicity

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