10.1007/s40204-019-00125-z

Bone tissue regeneration: biology, strategies and interface studies

  1. Department of Biomedical Engineering, Meybod University, Meybod, IR
Cover Image

Published in Issue 2019-11-25

How to Cite

Ansari, M. (2019). Bone tissue regeneration: biology, strategies and interface studies. Progress in Biomaterials, 8(4 (December 2019). https://doi.org/10.1007/s40204-019-00125-z

Abstract

Abstract Nowadays, bone diseases and defects as a result of trauma, cancers, infections and degenerative and inflammatory conditions are increasing. Consequently, bone repair and replacement have been developed with improvement of orthopedic technologies and biomaterials of superior properties. This review paper is intended to sum up and discuss the most relevant studies performed in the field of bone biology and bone regeneration approaches. Therefore, the bone tissue regeneration was investigated by synthetic substitutes, scaffolds incorporating active molecules, nanomedicine, cell-based products, biomimetic fibrous and nonfibrous substitutes, biomaterial-based three-dimensional (3D) cell-printing substitutes, bioactive porous polymer/inorganic composites, magnetic field and nano-scaffolds with stem cells and bone–biomaterials interface studies.

Keywords

  • Bone regeneration,
  • Biology,
  • Biomaterials,
  • Biocompatibility,
  • Tissue engineering

References

  1. Abid et al. (2017) Formulation and characterization of antimicrobial quaternary ammonium dendrimer in poly (methyl methcarylate) bone cement 105(3) (pp. 521-530)
  2. Aimaiti et al. (2011) Therapeutic effect of osteogenically induced adipose derived stem cells on vascular deprivation-induced osteonecrosis of the femoral head in rabbits 14(4) (pp. 215-220)
  3. Akkouch et al. (2014) Engineering bone tissue using human dental pulp stem cells and an osteogenic collagen-hydroxyapatite-poly (l-lactide-co-ɛ-caprolactone) scaffold 28(6) (pp. 922-936)
  4. Alvarez and Nakajima (2009) Metallic scaffolds for bone regeneration 2(3) (pp. 790-832)
  5. Ansari and Eshghanmalek (2019) Biomaterials for repair and regeneration of the cartilage tissue 2(1) (pp. 41-49)
  6. Ansari and Moztarzadeh (2012) Effect of the synthesis parameters on the properties of biphasic Ca (OH)-HA nanopowders for tissue engineering applications 8(1) (pp. 335-342)
  7. Ansari et al. (2011) Synthesis and characterisation of hydroxyapatite-calcium hydroxide for dental composites 55(2) (pp. 123-126)
  8. Ansari et al. (2018) Biodegradable cell-seeded collagen based polymer scaffolds for wound healing and skin reconstruction 57(2) (pp. 100-109)
  9. Arvidson et al. (2011) Bone regeneration and stem cells 15(4) (pp. 718-746)
  10. Baksh et al. (2004) Adult mesenchymal stem cells: characterization, differentiation, and application in cell and gene therapy 8(3) (pp. 301-316)
  11. Banerjee et al. (2011) Antifouling coatings: recent developments in the design of surfaces that prevent fouling by proteins, bacteria, and marine organisms 23(6) (pp. 690-718)
  12. Bateman et al. (2005) Platelet-derived growth factor enhancement of two alloplastic bone matrices 76(11) (pp. 1833-1841)
  13. Behzadi et al. (2017) Nanomedicine for safe healing of bone trauma: opportunities and challenges (pp. 168-182)
  14. Bessa et al. (2008) Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery) 2(2–3) (pp. 81-96)
  15. Bhatnagar et al. (1999) Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen 5(1) (pp. 53-65)
  16. Bostrom and Seigerman (2005) The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: a survey study 1(1) (pp. 9-18)
  17. Boyle et al. (2003) Osteoclast differentiation and activation 423(6937)
  18. Broos and Sermon (2004) From unstable internal fixation to biological osteosynthesis a historical overview of operative fracture treatment 104(4) (pp. 396-400)
  19. Bruder et al. (1994) Mesenchymal stem cells in bone development, bone repair, and skeletal regeneration therapy 56(3) (pp. 283-294)
  20. Burg et al. (2000) Biomaterial developments for bone tissue engineering 21(23) (pp. 2347-2359)
  21. Burleson and DiPaola (2019) 3D Printing in Spine Surgery (pp. 105-122)
  22. Cancedda et al. (2003) Tissue engineering and cell therapy of cartilage and bone 22(1) (pp. 81-91)
  23. Chen et al. (2008) Synthesis and characteristics of monticellite bioactive ceramic 19(3) (pp. 1257-1263)
  24. Chen et al. (2012) Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites 1(1)
  25. d’Aquino et al. (2008) Dental pulp stem cells: a promising tool for bone regeneration 4(1) (pp. 21-26)
  26. Di Bella et al. (2008) Bone regeneration in a rabbit critical-sized skull defect using autologous adipose-derived cells 14(4) (pp. 483-490)
  27. Diba et al. (2014) Magnesium-containing bioactive polycrystalline silicate-based ceramics and glass-ceramics for biomedical applications 18(3) (pp. 147-167)
  28. Dimitriou et al. (2005) Current concepts of molecular aspects of bone healing 36(12) (pp. 1392-1404)
  29. Dziadek et al. (2017) Biodegradable ceramic-polymer composites for biomedical applications: a review (pp. 1175-1191)
  30. Ekholm et al. (2005) Hydroxyapatite coating of cellulose sponge does not improve its osteogenic potency in rat bone 1(5) (pp. 535-544)
  31. Eslami et al. (2018) Poly (lactic-co-glycolic acid)(PLGA)/TiO2 nanotube bioactive composite as a novel scaffold for bone tissue engineering: in vitro and in vivo studies (pp. 51-62)
  32. Fathi-Achachelouei et al. (2019) Use of nanoparticles in tissue engineering and regenerative medicine
  33. Fitzsimmons et al. (1995) Combined magnetic fields increase insulin-like growth factor-II in TE-85 human osteosarcoma bone cell cultures 136(7) (pp. 3100-3106)
  34. Franz Odendaal et al. (2006) Buried alive: how osteoblasts become osteocytes 235(1) (pp. 176-190)
  35. Gan et al. (2018) Chitosan/biphasic calcium phosphate scaffolds functionalized with BMP-2-encapsulated nanoparticles and RGD for bone regeneration 106(10) (pp. 2613-2624)
  36. Gentile et al. (2014) An overview of poly (lactic-co-glycolic) acid (PLGA)-based biomaterials for bone tissue engineering 15(3) (pp. 3640-3659)
  37. Giannoudis et al. (2005) Bone substitutes: an update 36(3) (pp. S20-S27)
  38. Gonçalves et al. (2016) Bioengineered Strategies for Tendon Regeneration (pp. 275-293)
  39. Gu et al. (2013) Nanotechnology in the targeted drug delivery for bone diseases and bone regeneration
  40. Haidar et al. (2009) Delivery of recombinant bone morphogenetic proteins for bone regeneration and repair. Part B: delivery systems for BMPs in orthopaedic and craniofacial tissue engineering 31(12) (pp. 1825-1835)
  41. Hajipour et al. (2012) Antibacterial properties of nanoparticles 30(10) (pp. 499-511)
  42. He et al. (2009) Fabrication and characterization of poly (l-lactic acid) 3D nanofibrous scaffolds with controlled architecture by liquid–liquid phase separation from a ternary polymer–solvent system 50(16) (pp. 4128-4138)
  43. Helminen et al. (2002) Cross-linked poly (ε-caprolactone/d, l-lactide) copolymers with elastic properties 203(18) (pp. 2630-2639)
  44. Ho-Shui-Ling et al. (2018) Bone regeneration strategies: engineered scaffolds, bioactive molecules and stem cells current stage and future perspectives (pp. 143-162)
  45. Hu et al. (2018) Enhanced bone regeneration and visual monitoring via superparamagnetic iron oxide nanoparticle scaffold in rats 12(4) (pp. e2085-e2098)
  46. Hu et al. (2019) Bioinspired surface modification of orthopedic implants for bone tissue engineering
  47. Jang et al. (2018) Biomaterials-based 3D cell printing for next-generation therapeutics and diagnostics (pp. 88-106)
  48. Jin et al. (2013) Comparative analysis of human mesenchymal stem cells from bone marrow, adipose tissue, and umbilical cord blood as sources of cell therapy 14(9) (pp. 17986-18001)
  49. Jin et al. (2018) Electrospun three-dimensional aligned nanofibrous scaffolds for tissue engineering (pp. 995-1005)
  50. Join Lambert et al. (2005) Listeria monocytogenes-infected bone marrow myeloid cells promote bacterial invasion of the central nervous system 7(2) (pp. 167-180)
  51. Kalantari and Naghib (2019) A comparative study on biological properties of novel nanostructured monticellite-based composites with hydroxyapatite bioceramic (pp. 1087-1096)
  52. Kalantari et al. (2017) Green solvent-based sol–gel synthesis of monticellite nanoparticles: a rapid and efficient approach 84(1) (pp. 87-95)
  53. Kalantari et al. (2018) Nanostructured monticellite for tissue engineering applications—part I: microstructural and physicochemical characteristics 44(11) (pp. 12731-12738)
  54. Kalantari et al. (2018) Nanostructured monticellite for tissue engineering applications—part II: molecular and biological characteristics 44(12) (pp. 14704-14711)
  55. Kalantari et al. (2018) Nanostructured monticellite: an emerging player in tissue engineering 5(7, Part 3) (pp. 15744-15753)
  56. Kalantari et al. (2019) Biocomposites based on hydroxyapatite matrix reinforced with nanostructured monticellite (CaMgSiO4) for biomedical application: synthesis, characterization, and biological studies
  57. Ke et al. (2017) Reactive blends based on polyhydroxyalkanoates: preparation and biomedical application (pp. 1107-1119)
  58. Keselowsky et al. (2003) Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion 66(2) (pp. 247-259)
  59. Kim et al. (2006) Electrospinning biomedical nanocomposite fibers of hydroxyapatite/poly (lactic acid) for bone regeneration 79(3) (pp. 643-649)
  60. Kim et al. (2010) Epigenetic memory in induced pluripotent stem cells 467(7313)
  61. Kochesfahani (2016) (pp. 1598-1614) SPE ANTEC
  62. Kristjánsson et al. (2013) Mesenchymal stem cells for regeneration of cartilage lesions: focus on knee osteoarthritis 37(2–4) (pp. 67-78)
  63. Kular et al. (2012) An overview of the regulation of bone remodelling at the cellular level 45(12) (pp. 863-873)
  64. Lalzawmliana et al. (2019) Mesoporous bioactive glasses for bone healing and biomolecules delivery
  65. Lee and Shin (2007) Matrices and scaffolds for delivery of bioactive molecules in bone and cartilage tissue engineering 59(4–5) (pp. 339-359)
  66. Lendeckel et al. (2004) Autologous stem cells (adipose) and fibrin glue used to treat widespread traumatic calvarial defects: case report 32(6) (pp. 370-373)
  67. Li et al. (2018) Adaptive materials based on iron oxide nanoparticles for bone regeneration 19(16) (pp. 1965-1979)
  68. Lim et al. (2017) Emerging bone tissue engineering via polyhydroxyalkanoate (PHA)-based scaffolds (pp. 917-929)
  69. Liu et al. (2014) Cell proliferation and cell sheet detachment from the positively and negatively charged nanocomposite hydrogels 101(1) (pp. 58-65)
  70. Lizarraga-Valderrama et al. (2016) Biomedical Applications of Polyhydroxyalkanoates (pp. 337-383) John Wiley & Sons, Inc.
  71. Long et al. (2006) Titanium dioxide (P25) produces reactive oxygen species in immortalized brain microglia (BV2): implications for nanoparticle neurotoxicity 40(14) (pp. 4346-4352)
  72. Lu et al. (2012) The extracellular matrix: a dynamic niche in cancer progression 196(4) (pp. 395-406)
  73. Luginbuehl et al. (2004) Localized delivery of growth factors for bone repair 58(2) (pp. 197-208)
  74. Ma et al. (2007) Surface modification and property analysis of biomedical polymers used for tissue engineering 60(2) (pp. 137-157)
  75. McCarthy et al. (2007) Targeted delivery of multifunctional magnetic nanoparticles (pp. 153-167)
  76. Moshaverinia et al. (2012) Alginate hydrogel as a promising scaffold for dental-derived stem cells: an in vitro study 23(12) (pp. 3041-3051)
  77. Muzzarelli (2011) Chitosan composites with inorganics, morphogenetic proteins and stem cells, for bone regeneration 83(4) (pp. 1433-1445)
  78. Naghib et al. (2012) Bioactivation of 304 stainless steel surface through 45S5 bioglass coating for biomedical applications (pp. 2890-2903)
  79. Nickel et al. (2005) A single residue of GDF-5 defines binding specificity to BMP receptor IB 349(5) (pp. 933-947)
  80. Noble and Reeve (2000) Osteocyte function, osteocyte death and bone fracture resistance 159(1–2) (pp. 7-13)
  81. Omrani et al. (2016) Enhanced protein adsorption, cell attachment, and neural differentiation with the help of amine functionalized polycaprolactone scaffolds 55(6) (pp. 617-626)
  82. Omrani MM, Ansari M, Kordestani SS, Kiaie N, Salati A (2019) Enhanced bone marrow stem cell attachment and differentiation on PCL/CNT substrate. Inorganic and Nano-Metal Chemistry, pp 1–7
  83. Osathanon et al. (2017) Polycaprolactone-Based Biomaterials for Guided Tissue Regeneration Membrane
  84. Pajarinen et al. (2019) Mesenchymal stem cell-macrophage crosstalk and bone healing (pp. 80-89)
  85. Pakulska MM (2016) Combined delivery of chondroitinase ABC (ChABC) and stromal cell derived factor 1α (SDF1α) for spinal cord regeneration
  86. Panseri et al. (2012) Magnetic hydroxyapatite bone substitutes to enhance tissue regeneration: evaluation in vitro using osteoblast-like cells and in vivo in a bone defect 7(6)
  87. Perez et al. (2018) Tissue engineering and cell-based therapies for fractures and bone defects
  88. Place et al. (2009) Complexity in biomaterials for tissue engineering 8(6)
  89. Poehling et al. (2006) Superior effect of MD05, beta-tricalcium phosphate coated with recombinant human growth/differentiation factor-5, compared to conventional bone substitutes in the rat calvarial defect model 77(9) (pp. 1582-1590)
  90. Portale et al. (1984) Effect of dietary phosphorus on circulating concentrations of 1, 25-dihydroxyvitamin D and immunoreactive parathyroid hormone in children with moderate renal insufficiency 73(6) (pp. 1580-1589)
  91. Puleo and Nanci (1999) Understanding and controlling the bone–implant interface 20(23–24) (pp. 2311-2321)
  92. Puppi et al. (2010) Polymeric materials for bone and cartilage repair 35(4) (pp. 403-440)
  93. Qiu et al. (2019) Natural Bone Tissue and Its Biomimetic (pp. 1-22)
  94. Rather et al. (2019) Dual functional approaches for osteogenesis coupled angiogenesis in bone tissue engineering
  95. Rezwan et al. (2006) Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering 27(18) (pp. 3413-3431)
  96. Roseti et al. (2017) Scaffolds for bone tissue engineering: state of the art and new perspectives (pp. 1246-1262)
  97. Roshanbinfar and Ansari (2013) Investigating of mechanical and biological properties of porous hydroxyapatite scaffolds produced by novel shake gel casting method 3(3) (pp. 284-288)
  98. Samavedi et al. (2013) Calcium phosphate ceramics in bone tissue engineering: a review of properties and their influence on cell behavior 9(9) (pp. 8037-8045)
  99. Santhosh and Ulrih (2013) Multifunctional superparamagnetic iron oxide nanoparticles: promising tools in cancer theranostics 336(1) (pp. 8-17)
  100. Sarin and Rekhi (2016) Bioactive glass: a potential next generation biomaterial 7(1)
  101. Schade and Roukis (2010) The role of polymethylmethacrylate antibiotic–loaded cement in addition to debridement for the treatment of soft tissue and osseous infections of the foot and ankle 49(1) (pp. 55-62)
  102. Schindeler A, McDonald MM, Bokko P, Little DG (2008) Bone remodeling during fracture repair: the cellular picture. Paper presented at the seminars in cell and developmental biology
  103. Sheikh et al. (2019) Natural and synthetic bone replacement graft materials for dental and maxillofacial applications (pp. 347-376)
  104. Sikavitsas et al. (2001) Biomaterials and bone mechanotransduction 22(19) (pp. 2581-2593)
  105. Solchaga et al. (2012) Safety of recombinant human platelet-derived growth factor-BB in Augment® Bone Graft 3(1)
  106. Standring (2016) Elsevier
  107. Stumpf et al. (2018) In situ and ex situ modifications of bacterial cellulose for applications in tissue engineering (pp. 372-383)
  108. Tampieri et al. (2014) Magnetic bioinspired hybrid nanostructured collagen–hydroxyapatite scaffolds supporting cell proliferation and tuning regenerative process 6(18) (pp. 15697-15707)
  109. Tang et al. (2012) Human embryonic stem cell encapsulation in alginate microbeads in macroporous calcium phosphate cement for bone tissue engineering 8(9) (pp. 3436-3445)
  110. Teng et al. (2008) Three-layered membranes of collagen/hydroxyapatite and chitosan for guided bone regeneration 87(1) (pp. 132-138)
  111. Teti (2011) Bone development: overview of bone cells and signaling 9(4)
  112. Tormos (2016) Oklahoma State University
  113. Türk et al. (2019) Effect of solution and calcination time on sol-gel synthesis of hydroxyapatite 16(2) (pp. 311-318)
  114. Uskokovic et al. (2019) Bone mineral crystallinity governs the orchestration of ossification and resorption during bone remodeling https://doi.org/10.1021/acsbiomaterials.9b00255
  115. Vaidya et al. (2008) Complications in the use of rhBMP-2 in PEEK cages for interbody spinal fusions 21(8) (pp. 557-562)
  116. Venkatesh and Sen (2017) Mesenchymal stem cells as a source of dopaminergic neurons: a potential cell based therapy for Parkinson’s disease 12(4) (pp. 326-347)
  117. Von Recum and Van Kooten (1996) The influence of micro-topography on cellular response and the implications for silicone implants 7(2) (pp. 181-198)
  118. Wang and Yeung (2017) Bone grafts and biomaterials substitutes for bone defect repair: a review 2(4) (pp. 224-247)
  119. Wang et al. (2012) The predominant role of collagen in the nucleation, growth, structure and orientation of bone apatite 11(8)
  120. Wang et al. (2019) “Tree to Bone”: lignin-polycaprolactone nanofibers for hydroxyapatite biomineralization https://doi.org/10.1021/acs.biomac.9b00451
  121. Wei and Ma (2006) Macroporous and nanofibrous polymer scaffolds and polymer/bone-like apatite composite scaffolds generated by sugar spheres 78(2) (pp. 306-315)
  122. Wu et al. (2017) Deriving osteogenic cells from induced pluripotent stem cells for bone tissue engineering 23(1) (pp. 1-8)
  123. Xia et al. (2018) Injectable calcium phosphate scaffold with iron oxide nanoparticles to enhance osteogenesis via dental pulp stem cells 46(sup1) (pp. 423-433)
  124. Xia et al. (2018) Magnetic field and nano-scaffolds with stem cells to enhance bone regeneration (pp. 151-170)
  125. Xynos et al. (2001) Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass® 45S5 dissolution 55(2) (pp. 151-157)
  126. Yan et al. (2015) Current concepts and challenges in osteochondral tissue engineering and regenerative medicine 1(4) (pp. 183-200)
  127. Yi et al. (2016) Recent advances in nano scaffolds for bone repair
  128. Zhang et al. (2006) Poly (L-lactide)(PLLA)/multiwalled carbon nanotube (MWCNT) composite: characterization and biocompatibility evaluation 110(26) (pp. 12910-12915)
  129. Zhang et al. (2014) 3D-printed magnetic Fe3O4/MBG/PCL composite scaffolds with multifunctionality of bone regeneration, local anticancer drug delivery and hyperthermia 2(43) (pp. 7583-7595)
  130. Zheng et al. (2010) The use of BMP-2 coupled-nanosilver-PLGA composite grafts to induce bone repair in grossly infected segmental defects 31(35) (pp. 9293-9300)