10.1007/s40204-019-00124-0

Effect of anodized zirconium implants on early osseointegration process in adult rats: a histological and histomorphometric study

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  • María Florencia Tano de la Hoz1,
  • María Rosa Katunar1,
  • Ariel González2,
  • Andrea Gomez Sanchez3,
  • Alcira Ofelia Díaz4,
  • Silvia Ceré*1,
  1. INTEMA, Applied Electrochemistry Division, National University of Mar del Plata-CONICET, Mar del Plata, B7608FDQ, AR
  2. Biology Department, FCEyN, National University of Mar del Plata, Mar del Plata, B7602AYJ, AR
  3. CIT Villa María–CONICET, Villa María, 5900, AR UTN-FRVM, Villa María, 5900, AR
  4. Marine and Coastal Research Institute (IIMyC), Biology Department, FCEyN, National University of Mar del Plata-CONICET, Mar del Plata, B7602AYJ, AR
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Published in Issue 2019-11-22

How to Cite

Tano de la Hoz, M. F., Katunar, M. R., González, A., Gomez Sanchez, A., Díaz, A. O., & Ceré, S. (2019). Effect of anodized zirconium implants on early osseointegration process in adult rats: a histological and histomorphometric study. Progress in Biomaterials, 8(4 (December 2019). https://doi.org/10.1007/s40204-019-00124-0
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Abstract

Abstract Since surface plays a key role in bioactivity, the response of the host to the biomaterial will determine the success or failure of the prosthesis. The purpose of this study is to make an exhaustive analysis of the histological and histochemical characteristics of new bone tissue around Zr implants anodized at 60 V (Zr60) supported by histomorphometric methods in a rat model. Fibrous tissue was observed around the control implants (Zr0) and osteoblasts were identified on the trabeculae close to the implantation site that showed typical cytological characteristics of active secretory cells, regardless of the surface condition. The histomorphometrical analysis revealed a significant increase in cancellous bone volume, trabecular thickness and in trabecular number together with a decrease in trabecular separation facing Zr60. TRAP staining showed that there was a relative increase in the number of osteoclasts for Zr60. In addition, a larger number of osteoclast with a greater number of nuclei were detected in the tibiae for Zr60. This research demonstrated that the new bone microarchitecture in contact with Zr60 is able to improve the early stages of the osseointegration process and consequently the primary stability of implants which is a crucial factor to reduce recovery time for patients.

Keywords

  • Osseointegration,
  • Zirconium implants,
  • Anodization,
  • Histology,
  • Histomorphometry
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