10.1007/s40204-019-00120-4

Polyvinyl alcohol/soy protein isolate nanofibrous patch for wound-healing applications

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  • Bahareh Khabbaz1,
  • Atefeh Solouk*2,
  • Hamid Mirzadeh3,
  1. Biomedical Engineering Department, Faculty of Engineering, Islamic Azad University Central Tehran Branch, Tehran, 13185/867, IR
  2. Biomedical Engineering Department, Faculty of Engineering, Islamic Azad University Central Tehran Branch, Tehran, 13185/867, IR Biomedical Engineering Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 15875-4413, IR
  3. Polymer Engineering and Color Technology Department, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 15875-4413, IR
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Published in Issue 2019-09-24

How to Cite

Khabbaz, B., Solouk, A., & Mirzadeh, H. (2019). Polyvinyl alcohol/soy protein isolate nanofibrous patch for wound-healing applications. Progress in Biomaterials, 8(3 (September 2019). https://doi.org/10.1007/s40204-019-00120-4
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Abstract

Abstract Soy protein isolate (SPI), due to its biocompatibility, biodegradability, abundance and being inexpensive, is a suitable polymer for medical applications. In this study, electrospun nanofibrous mats (ENMs) and casting films (CFs), comprising polyvinyl alcohol (PVA)/SPI, were prepared and compared. Both crosslinked ENMs and CFs physical, chemical, mechanical, and biological properties were investigated for wound-healing applications. Considering the importance of exudate absorption by wound dressing the uptake test of all samples was performed in simulated exudate solution. The amount of absorbed exudate, water vapor transmission rate, and mechanical elongation for CFs were 69.243% ± 22.7, 266.7 g/m 2  day, and 2.0825% and increased to 383.33% ± 105.3, 1332.02 g/m 2  day, and 12.292% in the case of ENMs, respectively. There was no significant difference between cell supporting of the two samples due to similar composition and their non-toxic properties. The results showed that ENMs have promising potential in wound-healing applications.

Keywords

  • Soy protein isolate,
  • Electrospun nanofibrous mat,
  • Wound healing
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