10.1007/s40204-018-0093-2

Chitosan/polyethylene glycol fumarate blend films for wound dressing application: in vitro biocompatibility and biodegradability assays

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  • Azadehsadat Hashemi Doulabi1,
  • Hamid Mirzadeh*1,
  • Mohammad Imani2,
  • Shadab Bagheri-Khoulenjani1,
  1. Department of Polymer Engineering, Amirkabir University of Technology, Tehran, IR
  2. Department of Novel Drug Delivery Systems, Iran Polymer and Petrochemical Institute, Tehran, IR
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Published in Issue 2018-07-18

How to Cite

Hashemi Doulabi, A., Mirzadeh, H., Imani, M., & Bagheri-Khoulenjani, S. (2018). Chitosan/polyethylene glycol fumarate blend films for wound dressing application: in vitro biocompatibility and biodegradability assays. Progress in Biomaterials, 7(2 (June 2018). https://doi.org/10.1007/s40204-018-0093-2
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Abstract

Abstract Blending is one of the effective approaches in preparing tailored materials with a wide range of properties. Thus, chitosan-based polymers have been fabricated and used as wound dressings since they possess better properties than those of the constituent materials. The objective of this work was to evaluate the biocompatibility and biodegradability of biodegradable blend films based on polyethylene glycol- co -fumarate (PEGF) and chitosan (Ch). The blend films of Ch/PEGF were prepared by solution casting/solvent evaporation method. Degradation behavior of these blend films was evaluated in a simulated fluid at physiological pH supplemented with lysozyme at a concentration similar to that in human serum by weight loss of the films and changes in the pH of media. When the pH of incubation media was analyzed, with an increase of PEGF content in the blend films, the degradation rate increased accordingly. The pH of the media of samples was not significantly changed at any measured time point and all films kept their integrities during 28 days. The biocompatibility of the films and cell behavior on the surface of these films were investigated by in vitro tests. Biological assessment using mouse fibroblast cell line L929 on the blend films of Ch/PEGF indicated that films supported the attachment, spreading and proliferation of cells. Since the Ch/PEGF films are biocompatible with the tailored biodegradation rate, they might have a great prospective position in the application of wound dressings.

Keywords

  • Chitosan,
  • Blend,
  • Biodegradation,
  • Cell behaviour,
  • Wound dressing
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