10.1007/s40204-018-0091-4

Updates on the research and development of absorbable metals for biomedical applications

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  • Hendra Hermawan*1,
  1. Department of Mining, Metallurgical and Materials Engineering and CHU de Québec Research Center, Laval University, Quebec City, G1V 0A6, CA
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Published in Issue 2018-05-22

How to Cite

Hermawan, H. (2018). Updates on the research and development of absorbable metals for biomedical applications. Progress in Biomaterials, 7(2 (June 2018). https://doi.org/10.1007/s40204-018-0091-4
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Abstract

Abstract Absorbable metals, metals that corrode in physiological environment, constitute a new class of biomaterials intended for temporary medical implant applications. The introduction of these metals has shifted the established paradigm of metal implants from preventing corrosion to its direct application. Interest toward absorbable metals has been growing in the past decade. This is proved by the rapid increase in scientific publication, progressive development of standards, and launching the first commercial products. Iron, magnesium, zinc, and their alloys are the current three absorbable metals families. Magnesium-based metals are the most progressing family with a large data set obtained from both basic and translational research. Iron-based metals are still facing a major challenge of low in vivo corrosion rate despite the significant efforts that have been put to overcome its weakness. Zinc-based metals are the new alternative absorbable metals with moderate corrosion rates that fall between those of iron and magnesium. This manuscript provides a brief review on the latest progress in the research and development of absorbable metals, the most important findings, the remaining challenges, and the perspective on the future direction. Graphical abstract

Keywords

  • Absorbable,
  • Biodegradable,
  • Corrosion,
  • Iron,
  • Magnesium,
  • Metal,
  • Zinc
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References

  1. Aghion and Perez (2014) Effects of porosity on corrosion resistance of Mg alloy foam produced by powder metallurgy technology (pp. 78-83) https://doi.org/10.1016/j.matchar.2014.07.012
  2. Agrawal et al. (2016) Biodegradable magnesium alloys for orthopaedic applications: a review on corrosion, biocompatibility and surface modifications (pp. 948-963) https://doi.org/10.1016/j.msec.2016.06.020
  3. Alavi et al. (2017) Investigation on mechanical behavior of biodegradable iron foams under different compression test conditions https://doi.org/10.3390/met7060202
  4. Unknown (2013) ASTM International
  5. Unknown (2016) ASTM International
  6. Unknown (2016) ASTM International
  7. Unknown (2018) ASTM International
  8. Bartosch et al. (2015) Magnesium stents–fundamentals, biological implications and applications beyond coronary arteries (pp. 3-17) https://doi.org/10.1515/bnm-2015-0004
  9. Biber et al. (2017) Bioabsorbable metal screws in traumatology: a promising innovation (pp. 11-15) https://doi.org/10.1016/j.tcr.2017.01.012
  10. Bowen et al. (2015) Rates of in vivo (arterial) and in vitro biocorrosion for pure magnesium (pp. 341-349) https://doi.org/10.1002/jbm.a.35179
  11. Čapek et al. (2016) Microstructure, mechanical and corrosion properties of biodegradable powder metallurgical Fe-2 wt% X (X = Pd, Ag and C) alloys (pp. 501-511) https://doi.org/10.1016/j.matchemphys.2016.06.087
  12. Chaya et al. (2015) In vivo study of magnesium plate and screw degradation and bone fracture healing (pp. 262-269) https://doi.org/10.1016/j.actbio.2015.02.010
  13. Cheng et al. (2016) A novel open-porous magnesium scaffold with controllable microstructures and properties for bone regeneration https://doi.org/10.1038/srep24134
  14. Cui et al. (2017) Corrosion resistance of a self-healing micro-arc oxidation/polymethyltrimethoxysilane composite coating on magnesium alloy AZ31 (pp. 84-95) https://doi.org/10.1016/j.corsci.2017.01.025
  15. Cysewska et al. (2017) Tailoring the electrochemical degradation of iron protected with polypyrrole films for biodegradable cardiovascular stents (pp. 327-336) https://doi.org/10.1016/j.electacta.2017.05.172
  16. Dambatta et al. (2017) Processing of Zn-3 Mg alloy by equal channel angular pressing for biodegradable metal implants (pp. 455-461) https://doi.org/10.1016/j.jksus.2017.07.008
  17. Dehestani et al. (2016) Mechanical properties and corrosion behavior of powder metallurgy iron-hydroxyapatite composites for biodegradable implant applications (pp. 556-569) https://doi.org/10.1016/j.matdes.2016.07.092
  18. Drelich et al. (2017) Long-term surveillance of zinc implant in murine artery: surprisingly steady biocorrosion rate (pp. 539-549) https://doi.org/10.1016/j.actbio.2017.05.045
  19. Drynda et al. (2015) In vitro and in vivo corrosion properties of new iron–manganese alloys designed for cardiovascular applications (pp. 649-660) https://doi.org/10.1002/jbm.b.33234
  20. Feng et al. (2016) Novel Fe–Mn–Si–Pd alloys: insights into mechanical, magnetic, corrosion resistance and biocompatibility performances (pp. 6402-6412) https://doi.org/10.1039/C6TB01951J
  21. Feng et al. (2017) Mechanical properties, corrosion performance and cell viability studies on newly developed porous Fe–Mn–Si–Pd alloys (pp. 1046-1056) https://doi.org/10.1016/j.jallcom.2017.07.112
  22. Francis et al. (2015) Iron and iron-based alloys for temporary cardiovascular applications (pp. 1-16) https://doi.org/10.1007/s10856-015-5473-8
  23. Gong et al. (2015) In vitro biodegradation behavior, mechanical properties, and cytotoxicity of biodegradable Zn–Mg alloy (pp. 1632-1640) https://doi.org/10.1002/jbm.b.33341
  24. Gordeladze et al. (2017) Wiley
  25. Griebel et al. (2017) An in vitro and in vivo characterization of fine WE43B magnesium wire with varied thermomechanical processing conditions https://doi.org/10.1002/jbm.b.34008
  26. Guillory et al. (2016) Corrosion characteristics dictate the long-term inflammatory profile of degradable zinc arterial implants (pp. 2355-2364) https://doi.org/10.1021/acsbiomaterials.6b00591
  27. Han et al. (2015) In vitro and in vivo studies on the degradation of high-purity Mg (99.99 wt%) screw with femoral intracondylar fractured rabbit model (pp. 57-69) https://doi.org/10.1016/j.biomaterials.2015.06.031
  28. Haude et al. (2016) Safety and performance of the DRug-eluting absorbable metal scaffold (DREAMS) in patients with de novo coronary lesions: 3-year results of the prospective, multicentre, first-in-man BIOSOLVE-I trial (pp. e160-e166) https://doi.org/10.4244/EIJ-D-15-00371
  29. Haude et al. (2016) Safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de-novo coronary artery lesions (BIOSOLVE-II): 6 month results of a prospective, multicentre, non-randomised, first-in-man trial (pp. 31-39) https://doi.org/10.1016/S0140-6736(15)00447-X
  30. Haude et al. (2016) Sustained safety and performance of the second-generation drug-eluting absorbable metal scaffold in patients with de novo coronary lesions: 12-month clinical results and angiographic findings of the BIOSOLVE-II first-in-man trial (pp. 2701-2709) https://doi.org/10.1093/eurheartj/ehw196
  31. Haude et al. (2017) Sustained safety and clinical performance of a drug-eluting absorbable metal scaffold up to 24 months: pooled outcomes of BIOSOLVE-II and BIOSOLVE-III (pp. 432-439) https://doi.org/10.4244/EIJ-D-17-00254
  32. Hayes (2016) Wiley
  33. He et al. (2016) Advances in Fe-based biodegradable metallic materials (pp. 112819-112838) https://doi.org/10.1039/C6RA20594A
  34. Heiden et al. (2016) Surface modifications through dealloying of Fe–Mn and Fe–Mn–Zn alloys developed to create tailorable, nanoporous, bioresorbable surfaces (pp. 115-127) https://doi.org/10.1016/j.actamat.2015.10.002
  35. Hiromoto et al. (2015) In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite (pp. 520-530) https://doi.org/10.1016/j.actbio.2014.09.026
  36. Hofstetter et al. (2015) Assessing the degradation performance of ultrahigh-purity magnesium in vitro and in vivo (pp. 29-36) https://doi.org/10.1016/j.corsci.2014.09.008
  37. HORIZONS (2016) Episode 13: medical diagnostics and delivery—drug and disease [Online]. BBC. Available:
  38. http://www.bbc.com/specialfeatures/horizonsbusiness/seriesfour/episode-13-medical-dd/?vid=p029nb4j
  39. . Accessed 2017/06/30 2016
  40. Huang et al. (2016) In vitro studies on silver implanted pure iron by metal vapor vacuum arc technique (pp. 20-29) https://doi.org/10.1016/j.colsurfb.2016.01.065
  41. Hufenbach et al. (2017) Novel biodegradable Fe–Mn–C–S alloy with superior mechanical and corrosion properties (pp. 330-333) https://doi.org/10.1016/j.matlet.2016.10.037
  42. Unknown (2014) ISO
  43. Unknown (2014) ISO
  44. Unknown (2018) ISO
  45. Unknown (2018) ISO
  46. Johnston et al. (2018) Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion (pp. 475-500) https://doi.org/10.1007/s40843-017-9173-7
  47. Kim et al. (2016) Biomolecular strategies to modulate the macrophage response to implanted materials (pp. 1600-1609) https://doi.org/10.1039/C5TB01605C
  48. Koo et al. (2017) USPTO
  49. Kraus et al. (2014) Biodegradable Fe-based alloys for use in osteosynthesis: outcome of an in vivo study after 52 weeks (pp. 3346-3353) https://doi.org/10.1016/j.actbio.2014.04.007
  50. Kubásek et al. (2016) Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn–Mg alloys (pp. 24-35) https://doi.org/10.1016/j.msec.2015.08.015
  51. Lee et al. (2016) Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy (pp. 716-721) https://doi.org/10.1073/pnas.1518238113
  52. Levy et al. (2017) Evaluation of biodegradable Zn–1% Mg and Zn−1% Mg-0.5% Ca alloys for biomedical applications https://doi.org/10.1007/s10856-017-5973-9
  53. Li et al. (2016) Design of magnesium alloys with controllable degradation for biomedical implants: from bulk to surface (pp. 2-30) https://doi.org/10.1016/j.actbio.2016.09.005
  54. Li et al. (2018) Effects of scandium addition on biocompatibility of biodegradable Mg–1.5Zn–0.6Zr alloy (pp. 200-202) https://doi.org/10.1016/j.matlet.2017.12.097
  55. Lin et al. (2016) Design and characterization of a novel biocorrodible iron-based drug-eluting coronary scaffold (pp. 72-79) https://doi.org/10.1016/j.matdes.2015.11.045
  56. Lin et al. (2017) Long-term in vivo corrosion behavior, biocompatibility and bioresorption mechanism of a bioresorbable nitrided iron scaffold (pp. 454-468) https://doi.org/10.1016/j.actbio.2017.03.020
  57. Liu et al. (2016) Microstructure, mechanical properties, in vitro degradation behavior and hemocompatibility of novel Zn–Mg–Sr alloys as biodegradable metals (pp. 242-245) https://doi.org/10.1016/j.matlet.2015.07.151
  58. Liu et al. (2016) Micro-alloying with Mn in Zn–Mg alloy for future biodegradable metals application (pp. 95-104) https://doi.org/10.1016/j.matdes.2015.12.128
  59. Liu et al. (2017) A novel biodegradable and biologically functional arginine-based poly (ester urea urethane) coating for Mg–Zn–Y–Nd alloy: enhancement in corrosion resistance and biocompatibility (pp. 1787-1802) https://doi.org/10.1039/C6TB03147A
  60. Liu et al. (2017) Degradable, absorbable or resorbable—what is the best grammatical modifier for an implant that is eventually absorbed by the body? (pp. 377-391) https://doi.org/10.1007/s40843-017-9023-9
  61. Loeffler et al. (2017) USPTO
  62. Mao et al. (2017) A promising biodegradable magnesium alloy suitable for clinical vascular stent application https://doi.org/10.1038/srep46343
  63. Marco et al. (2017) In vivo and in vitro degradation comparison of pure Mg, Mg-10Gd and Mg-2Ag: a short term study (pp. 90-104) https://doi.org/10.22203/eCM.v033a07
  64. Mostaed et al. (2014) Microstructure, texture evolution, mechanical properties and corrosion behavior of ECAP processed ZK60 magnesium alloy for biodegradable applications (pp. 307-322) https://doi.org/10.1016/j.jmbbm.2014.05.024
  65. Mostaed et al. (2016) Novel Zn-based alloys for biodegradable stent applications: design, development and in vitro degradation (pp. 581-602) https://doi.org/10.1016/j.jmbbm.2016.03.018
  66. Mostaed et al. (2018) Zinc-based alloys for degradable vascular stent applications (pp. 1-23) https://doi.org/10.1016/j.actbio.2018.03.005
  67. Murni et al. (2015) Cytotoxicity evaluation of biodegradable Zn–3 Mg alloy toward normal human osteoblast cells (pp. 560-566) https://doi.org/10.1016/j.msec.2015.01.056
  68. Myrissa et al. (2016) In vitro and in vivo comparison of binary Mg alloys and pure Mg (pp. 865-874) https://doi.org/10.1016/j.msec.2015.12.064
  69. Natasha et al. (2018) Monitoring magnesium degradation using microdialysis and fabric-based biosensors (pp. 643-651) https://doi.org/10.1007/s40843-017-9069-3
  70. Neubert and Schavan (2016) USPTO
  71. Paramitha D, Ulum MF, Purnama A, Wicaksono DHB, Noviana D, Hermawan H (2017) Monitoring degradation products and metal ions in vivo. In: Narayan RJ (ed) Monitoring and evaluation of biomaterials and their performance in vivo. Woodhead Publishing, pp 19–44.
  72. https://doi.org/10.1016/B978-0-08-100603-0.00002-X
  73. Patil et al. (2017) Anticorrosive self-assembled hybrid alkylsilane coatings for resorbable magnesium metal devices (pp. 518-529) https://doi.org/10.1021/acsbiomaterials.6b00585
  74. Plaass et al. (2016) Early results using a biodegradable magnesium screw for modified chevron osteotomies (pp. 2207-2214) https://doi.org/10.1002/jor.23241
  75. Plaass et al. (2018) Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies—3 year results of a randomized clinical trial (pp. 321-327) https://doi.org/10.1016/j.jos.2017.11.005
  76. Qi et al. (2018) Strategy of metal-polymer composite stent to accelerate biodegradation of iron-based biomaterials (pp. 182-192) https://doi.org/10.1021/acsami.7b15206
  77. Qu et al. (2017) In vivo and in vitro assessment of the biocompatibility and degradation of high-purity Mg anastomotic staples (pp. 1203-1214) https://doi.org/10.1177/0885328217692948
  78. Saad et al. (2016) Dynamic degradation of porous magnesium under a simulated environment of human cancellous bone (pp. 495-506) https://doi.org/10.1016/j.corsci.2016.08.017
  79. Sanchez et al. (2015) Mg and Mg alloys: how comparable are in vitro and in vivo corrosion rates? A review (pp. 16-31) https://doi.org/10.1016/j.actbio.2014.11.048
  80. Shearier et al. (2016) In vitro cytotoxicity, adhesion, and proliferation of human vascular cells exposed to zinc (pp. 634-642) https://doi.org/10.1021/acsbiomaterials.6b00035
  81. Shi et al. (2017) Enhanced corrosion resistance and cytocompatibility of biodegradable Mg alloys by introduction of Mg (OH)2 particles into poly (L-lactic acid) coating https://doi.org/10.1038/srep41796
  82. Sikora Jasinska et al. (2018) Long-term in vitro degradation behaviour of Fe and Fe/Mg2 Si composites for biodegradable implant applications (pp. 9627-9639) https://doi.org/10.1039/C8RA00404H
  83. Sotoudehbagha et al. (2018) Novel antibacterial biodegradable Fe–Mn–Ag alloys produced by mechanical alloying (pp. 88-94) https://doi.org/10.1016/j.msec.2018.03.005
  84. Su et al. (2016) Improvement of the biodegradation property and biomineralization ability of magnesium-hydroxyapatite composites with dicalcium phosphate dihydrate and hydroxyapatite coatings (pp. 818-828) https://doi.org/10.1021/acsbiomaterials.6b00013
  85. Sunil et al. (2016) In vitro and in vivo studies of biodegradable fine grained AZ31 magnesium alloy produced by equal channel angular pressing (pp. 356-367) https://doi.org/10.1016/j.msec.2015.10.028
  86. Ulum et al. (2015) Evidences of in vivo bioactivity of Fe-bioceramic composites for temporary bone implants (pp. 1354-1365) https://doi.org/10.1002/jbm.b.33315
  87. Vojtech et al. (2015) Comparative mechanical and corrosion studies on magnesium, zinc and iron alloys as biodegradable metals (pp. 877-882)
  88. Wang et al. (2014) Investigation into the hot workability of the as-extruded WE43 magnesium alloy using processing map (pp. 270-278) https://doi.org/10.1016/j.jmbbm.2014.01.011
  89. Wang et al. (2016) In vitro evaluation of the feasibility of commercial Zn alloys as biodegradable metals (pp. 909-918) https://doi.org/10.1016/j.jmst.2016.06.003
  90. Wang et al. (2016) Flow-induced corrosion of absorbable magnesium alloy: in-situ and real-time electrochemical study (pp. 277-289) https://doi.org/10.1016/j.corsci.2015.12.020
  91. Wang et al. (2016) Topological design and additive manufacturing of porous metals for bone scaffolds and orthopaedic implants: a review (pp. 127-141) https://doi.org/10.1016/j.biomaterials.2016.01.012
  92. Wang et al. (2017) In vitro corrosion properties and cytocompatibility of Fe–Ga alloys as potential biodegradable metallic materials (pp. 60-66) https://doi.org/10.1016/j.msec.2016.09.086
  93. Wang et al. (2017) In vitro degradation and surface bioactivity of iron-matrix composites containing silicate-based bioceramic (pp. 10-18) https://doi.org/10.1016/j.bioactmat.2016.12.001
  94. Witecka et al. (2016) Influence of biodegradable polymer coatings on corrosion, cytocompatibility and cell functionality of Mg-2.0Zn-0.98Mn magnesium alloy (pp. 284-292) https://doi.org/10.1016/j.colsurfb.2016.04.021
  95. Yang et al. (2017) Evolution of the degradation mechanism of pure zinc stent in the one-year study of rabbit abdominal aorta model (pp. 92-105) https://doi.org/10.1016/j.biomaterials.2017.08.022
  96. Yang et al. (2018) 3D printed Fe scaffolds with HA nanocoating for bone regeneration (pp. 608-616) https://doi.org/10.1021/acsbiomaterials.7b00885
  97. Yazdimamaghani et al. (2017) Porous magnesium-based scaffolds for tissue engineering (pp. 1253-1266) https://doi.org/10.1016/j.msec.2016.11.027
  98. Yu et al. (2017) In vitro and in vivo evaluation of MgF2 coated AZ31 magnesium alloy porous scaffolds for bone regeneration (pp. 330-340) https://doi.org/10.1016/j.colsurfb.2016.10.037
  99. Yue et al. (2015) Effectiveness of biodegradable magnesium alloy stents in coronary artery and femoral artery (pp. 358-364) https://doi.org/10.1111/joic.12217
  100. Yue et al. (2017) Microstructure, mechanical properties and in vitro degradation behavior of novel Zn–Cu–Fe alloys (pp. 114-122) https://doi.org/10.1016/j.matchar.2017.10.015
  101. Yusop et al. (2015) Controlling the degradation kinetics of porous iron by poly(lactic-co-glycolic acid) infiltration for use as temporary medical implants https://doi.org/10.1038/srep11194
  102. Zander and Zumdick (2015) Influence of Ca and Zn on the microstructure and corrosion of biodegradable Mg–Ca–Zn alloys (pp. 222-233) https://doi.org/10.1016/j.corsci.2015.01.027
  103. Zhao et al. (2016) Monitoring biodegradation of magnesium implants with sensors (pp. 1204-1208) https://doi.org/10.1007/s11837-015-1775-z
  104. Zhao et al. (2016) Visual H2 sensor for monitoring biodegradation of magnesium implants in vivo (pp. 399-409) https://doi.org/10.1016/j.actbio.2016.08.049
  105. Zhao et al. (2016) In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor (pp. 361-368) https://doi.org/10.1016/j.actbio.2016.03.039
  106. Zhao et al. (2016) Mechanical properties and in vitro biodegradation of newly developed porous Zn scaffolds for biomedical applications (pp. 136-144) https://doi.org/10.1016/j.matdes.2016.06.080
  107. Zhao et al. (2017) In vivo characterization of magnesium alloy biodegradation using electrochemical H2 monitoring, ICP-MS, and XPS (pp. 556-565) https://doi.org/10.1016/j.actbio.2017.01.024
  108. Zhao et al. (2017) Current status on clinical applications of magnesium-based orthopaedic implants: a review from clinical translational perspective (pp. 287-302) https://doi.org/10.1016/j.biomaterials.2016.10.017
  109. Zheng et al. (2014) Biodegradable metals (pp. 1-34) https://doi.org/10.1016/j.mser.2014.01.001
  110. Zhu et al. (2016) Silicone-covered biodegradable magnesium-stent insertion in the esophagus: a comparison with plastic stents (pp. 11-19) https://doi.org/10.1177/1756283X16671670
  111. Zhu et al. (2017) Technical feasibility and tissue reaction after silicone-covered biodegradable magnesium stent insertion in the oesophagus: a primary study in vitro and in vivo (pp. 2546-2553) https://doi.org/10.1007/s00330-016-4602-1