10.1007/s40204-018-0089-y

Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold

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  • Samira Nokhasteh1,
  • Alireza Sadeghi-avalshahr1,
  • Amir Mahdi Molavi*1,
  • Mohammad Khorsand-Ghayeni1,
  • Hojjat Naderi-Meshkin2,
  1. Department of Materials Research, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, 91775-1376, IR
  2. Stem Cell and Regenerative Medicine Research Department, Iranian Academic Center for Education, Culture and Research (ACECR), Mashhad, 91775-1376, IR
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Published in Issue 2018-05-11

How to Cite

Nokhasteh, S., Sadeghi-avalshahr, A., Molavi, A. M., Khorsand-Ghayeni, M., & Naderi-Meshkin, H. (2018). Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold. Progress in Biomaterials, 7(2 (June 2018). https://doi.org/10.1007/s40204-018-0089-y
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Abstract

Abstract Bioactive glasses have shown some interesting biological properties such as biocompatibility, biodegradation, and angiogenesis in skin tissue engineering. In the current research, the effects of MgO- or CoO-doped 64S bioactive glass with a composition of 64 SiO 2 -26 CaO-5 P 2 O 5 -5 MgO or CoO (mol%) were studied in relation with biological properties of electrospun [poly(lactic- co -glycolic acid) (PLGA)/collagen]. PLGA/collagen samples were rinsed in suspension of bioactive glass nanoparticles in distilled water with a concentration of 0.1 w/v and then freeze dried. Cell adhesion, viability, angiogenesis, and ionic release were performed and tested in culture medium containing fibroblast cells. Attachment and viability of fibroblast cells were increased significantly in bioglass-coated samples, while shrinkage in PLGA/collagen scaffold was reduced by the addition of bioactive glass. Vascular endothelial growth factor secretion in coated scaffold was dropped compared to the uncoated samples. This could be attributed to the fast degradation of glass nanoparticles, according to the inductively coupled plasma-atomic emission spectroscopy results.

Keywords

  • 64S bioactive glass,
  • PLGA/collagen,
  • Ionic release,
  • Skin substitute
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